Effusion cytology of epithelioid rhabdomyosarcoma

We report a case of epithelioid rhabdomyosarcoma in a pleural effusion. In contrast to most rhabdomyosarcomas in effusions, the cells presented as cohesive clusters of atypical cells with abundant eosinophilic cytoplasm which mimicked an adenocarcinoma. Immunohistochemistry was positive for epitheli...

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Bibliographic Details
Published in:Diagnostic cytopathology 2019-10, Vol.47 (10), p.1042-1044
Main Authors: Renshaw, Andrew A., Gould, Edwin W.
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma - pathology
Biomarkers, Tumor - metabolism
Case reports
Cytology
Cytoplasm
Diagnosis, Differential
effusion
Epithelioid Cells - metabolism
Epithelioid Cells - pathology
epithelioid rhabdomyosarcoma
Humans
Immunohistochemistry
Leukocytes (eosinophilic)
Male
Middle Aged
Muscles
Pleural effusion
Pleural Effusion, Malignant - pathology
Rhabdomyosarcoma
Rhabdomyosarcoma - pathology
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Summary:We report a case of epithelioid rhabdomyosarcoma in a pleural effusion. In contrast to most rhabdomyosarcomas in effusions, the cells presented as cohesive clusters of atypical cells with abundant eosinophilic cytoplasm which mimicked an adenocarcinoma. Immunohistochemistry was positive for epithelial membrane antigen and muscle markers and negative for keratins.
ISSN:8755-1039
1097-0339
DOI:10.1002/dc.24194