Kallikarein‐related peptidase 3 common genetic variant and the risk of prostate cancer

Kallikarein‐related peptidase 3 (KLK3) gene polymorphisms seem to play a role in susceptibility to prostate cancer (PC). The purpose of this study was to investigate the association between rs2735839 polymorphism of KLK3 gene and risk of PC in an Iranian population. In this case‐control study, rs273...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cellular biochemistry 2019-09, Vol.120 (9), p.14822-14830
Main Authors: Motamedi, Rouhollah K., Sarhangi, Negar, Afshari, Mahdi, Sattari, Mahshid, Jamaldini, Seyed H., Samzadeh, Mohammad, Mohsen Ziaei, Seyed A., Pourmand, Gholam R., Hasanzad, Mandana
Format: Article
Language:English
Subjects:
Antigens
Confidence intervals
Gene frequency
Gene polymorphism
Genetic diversity
Genetic variance
Genetic Variant
Genotypes
Health risks
Hyperplasia
KLK3
KLK3 gene
Levels
Peptidase
Polymerase chain reaction
Polymorphism
Prostate Cancer
Restriction fragment length polymorphism
Risk analysis
Risk factors
Statistical analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Kallikarein‐related peptidase 3 (KLK3) gene polymorphisms seem to play a role in susceptibility to prostate cancer (PC). The purpose of this study was to investigate the association between rs2735839 polymorphism of KLK3 gene and risk of PC in an Iranian population. In this case‐control study, rs2735839 was genotyped in 532 patients with PC and 602 controls with benign prostate hyperplasia (BPH) using polymerase chain reaction‐restriction fragment length polymorphism assay. The frequency of GG, AG, and AA genotypes of KLK3 polymorphism was 24.6% and 76.2%, 46.6% and 21.7%, and 28.8% and 2.1%, in patients with BPH and PC, respectively (P 
ISSN:0730-2312
1097-4644
DOI:10.1002/jcb.28743