Strepantibins A–C: Hexokinase II Inhibitors from a Mud Dauber Wasp Associated Streptomyces sp

Two new p-terphenyls, strepantibins A and B (1 and 2), along with the first representative of a naturally occurring bisphenyltropone, strepantibin C (3), were characterized from a Streptomyces sp. associated with the larvae of the mud dauber wasp Sceliphron madraspatanum. Their structures were deter...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2019-05, Vol.82 (5), p.1114-1119
Main Authors: Song, Ya-Jie, Zheng, Hong-Bo, Peng, Ai-Hong, Ma, Jia-Hui, Lu, Dan-Dan, Li, Xia, Zhang, Hang-Yu, Xie, Wei-Dong
Format: Article
Language:English
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Summary:Two new p-terphenyls, strepantibins A and B (1 and 2), along with the first representative of a naturally occurring bisphenyltropone, strepantibin C (3), were characterized from a Streptomyces sp. associated with the larvae of the mud dauber wasp Sceliphron madraspatanum. Their structures were determined by high-resolution electrospray ionization mass spectrometry, NMR, and X-ray crystallography data interpretation. Strepantibins A–C inhibited hexokinase II (HK2) activity and displayed antiproliferative activity against hepatoma carcinoma cells HepG-2, SMMC-7721 and plc-prf-5. In SMMC-7721 cells treated with strepantibin A, the morphological characteristics of apoptosis were observed.
ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.8b00821