The Nuclear Arsenal of Cilia

Several recent studies have revealed that nuclei and cilia share molecular components implicated in DNA damage response, splicing, gene expression, and sub-compartmentalization of the cell. We review evidence that exchange of components between the nucleus and cilia is facilitated by the centrosome,...

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Bibliographic Details
Published in:Developmental cell 2019-04, Vol.49 (2), p.161-170
Main Authors: Johnson, Colin A., Malicki, Jarema J.
Format: Article
Language:English
Subjects:
Animals
basal body
Cell Nucleus - metabolism
Cell Nucleus - physiology
Centrosome - metabolism
cilia
Cilia - genetics
Cilia - metabolism
Cilia - physiology
DNA Damage - physiology
evolution
Humans
mitosis
Mitosis - physiology
nuclear pore
Nuclear Pore - metabolism
nucleus
RNA Splicing
Spindle Apparatus - metabolism
transport
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Summary:Several recent studies have revealed that nuclei and cilia share molecular components implicated in DNA damage response, splicing, gene expression, and sub-compartmentalization of the cell. We review evidence that exchange of components between the nucleus and cilia is facilitated by the centrosome, which contributes both to the mitotic apparatus of the nucleus and to the cilia structure. Moreover, the centrosome and the pericentriolar material form condensates that share components with stress granules and P-bodies, membrane-less organelles enriched in RNA and RNA-processing proteins. These features may largely explain the origin of similar molecular mechanisms in nuclei and cilia. Several recent studies have revealed that nuclei and cilia share some molecular components. In this perspective, Johnson and Malicki review evidence for the exchange of components between the nucleus and cilia, which may explain the origin of similar molecular mechanisms in these organelles.
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2019.03.009