Diastolic wall strain predicts progression from paroxysmal to persistent or permanent atrial fibrillation in structurally normal hearts

•Atrial fibrillation (AF) is a progressive disease, with a gradual shift to persistent form.•Diastolic wall strain (DWS) is a measure of left ventricular stiffness.•DWS predicted progression of paroxysmal to persistent AF.•DWS could be used to stratify patients at risk for AF progression. Atrial fib...

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Bibliographic Details
Published in:Journal of cardiology 2019-10, Vol.74 (4), p.339-346
Main Authors: Uetake, Shunsuke, Maruyama, Mitsunori, Mitsuishi, Tatsuya, Takahashi, Kenta, Miyauchi, Yasushi, Seino, Yoshihiko, Shimizu, Wataru
Format: Article
Language:English
Subjects:
Atrial fibrillation
Echocardiography
Prognosis
Progression
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Summary:•Atrial fibrillation (AF) is a progressive disease, with a gradual shift to persistent form.•Diastolic wall strain (DWS) is a measure of left ventricular stiffness.•DWS predicted progression of paroxysmal to persistent AF.•DWS could be used to stratify patients at risk for AF progression. Atrial fibrillation (AF) is characterized by a progression from paroxysmal to persistent or permanent AF. Recent studies have shown that AF progression is related to a worse morbidity and mortality, and poorer outcomes of radiofrequency catheter ablation (RFCA). We previously showed that left ventricular (LV) compliance assessed by diastolic wall strain (DWS) was a strong determinant of prevalent AF. We studied 306 paroxysmal AF patients with structurally normal hearts. The DWS was non-invasively measured with echocardiography. During a follow-up of 35±19 months, AF progression occurred in 60 of 172 (35%) patients treated with medications only (medication group), and 3 of 134 (2%) who underwent RFCA (RFCA group) (p
ISSN:0914-5087
1876-4738
DOI:10.1016/j.jjcc.2019.03.016