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Impact of inter- and intra-observer variabilities of catheter reconstruction on multi-catheter interstitial brachytherapy of breast cancer patients
The aim of this study was to evaluate inter- and intra-observer variabilities of catheter reconstruction and its dosimetric impact for multi-catheter interstitial breast cancer patients. In order to evaluate inter-observer variabilities (IOV) three medical physicists reconstructed the catheter trace...
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Published in: | Radiotherapy and oncology 2019-06, Vol.135, p.25-32 |
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Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | The aim of this study was to evaluate inter- and intra-observer variabilities of catheter reconstruction and its dosimetric impact for multi-catheter interstitial breast cancer patients.
In order to evaluate inter-observer variabilities (IOV) three medical physicists reconstructed the catheter traces of 13 patients. These manual reconstructions were further compared to the automatic reconstruction algorithm integrated into the planning system and one on purpose imprecise manual reconstruction. For intra-observer variabilities (IAV) repeated reconstructions of two physicists were compared for 13 patients. In total 426 catheters were considered. Keeping dwell times, dwell positions, the optimization and the normalization relative points constant the geometrical deviations between the corresponding dwell positions of the reference data set and the investigated reconstructions were evaluated. Also, the effect on the quality indices, such as coverage index (CI), dose non-uniformity ratio (DNR) or conformal index (COIN), and the exposure of the organs at risk were analyzed.
Over all patients and all different catheter reconstructions considered for IOV a mean deviation between the corresponding dwell positions of 0.60 ± 0.35 mm was detected. The first observer had a mean deviation of 0.54 ± 0.32 mm, whereas the second observer yielded a mean deviation of 0.58 ± 0.37 mm. The length of the catheter traces varied in the mean by 0.51 ± 0.45 mm. The mean relative deviation of the CI, DNR, COIN, mean heart dose and mean lung dose varied by 0.27 ± 0.31%, 0.0027 ± 0.0025, 0.0036 ± 0.0033, 0.024 ± 0.019%, 0.05 ± 0.11%, respectively. The skin dose (D0.2ccm) changed in the maximum 8.52%. On average IAV reached a deviation between the corresponding dwell positions of 0.49 ± 0.30 mm. IOVs and IAVs proved to be significantly different (Wilcoxon’s test p |
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ISSN: | 0167-8140 1879-0887 |
DOI: | 10.1016/j.radonc.2019.02.017 |