Algrizea Minor Sobral, Faria & Proença (Myrteae, Myrtaceae): chemical composition, antinociceptive, antimicrobial and antioxidant activity of essential oil

This work aimed to investigate the chemical composition, antimicrobial, antinociceptive, acute toxicity and antioxidant activity of the essential oil of (EOAm). The essential oil presented as the major constituents β-Pinene (56.99%), α-Pinene (16.57%), Germacrene D (4.67%), Bicyclogermacrene (4.66%)...

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Bibliographic Details
Published in:Natural product research 2020-10, Vol.34 (20), p.3013-3017
Main Authors: de Veras, Bruno Oliveira, Dos Santos, Yago Queiroz, Oliveira, Fernanda Granja da Silva, Almeida, Jackson Roberto Guedes da Silva, da Silva, Alexandre Gomes, Correia, Maria Tereza Dos Santos, Diniz, Katharina Marques, de Oliveira, João Ricardhis Saturnino, Lima, Vera Lúcia de Menezes, Navarro, Daniela Maria do Amaral Ferraz, de Aguiar, Júlio César Ribeiro de Oliveira Farias, de Oliveira, Maria Betânia Melo, Lopes, Ana Catarina de Souza, da Silva, Márcia Vanusa
Format: Article
Language:English
Subjects:
Acute toxicity
Antiinfectives and antibacterials
Antioxidants
Bacteria
Bicyclogermacrene
Caryophyllene
Chemical composition
Essential oils
Fungi
Germacrene
Gram-negative bacteria
Limonene
Morphine
Oils & fats
Opioids
Pain
Pain perception
Toxicity
α-Pinene
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Summary:This work aimed to investigate the chemical composition, antimicrobial, antinociceptive, acute toxicity and antioxidant activity of the essential oil of (EOAm). The essential oil presented as the major constituents β-Pinene (56.99%), α-Pinene (16.57%), Germacrene D (4.67%), Bicyclogermacrene (4.66%), (E)-Caryophyllene (3.76%) and Limonene (1.71%). It was verified that the essential oil did not show acute toxicity in the maximum dose of 5,000 mg/kg. In the evaluation of the antinociceptive activity it was verified that the essential oil reduced in 65.84% the number of writhing in the mice, reducing the pain in 59.17%, and the mechanism of action in pain reduction was opioid, similar to morphine. The essential oil also presented significant antimicrobial against Gram positive and Gram-negative bacteria and fungi, and the antioxidant activity was relevant. Therefore, these results demonstrate the great potential for the future development of pharmaceutical products with the essential oil of .[Figure: see text].
ISSN:1478-6419
1478-6427
1478-6427
DOI:10.1080/14786419.2019.1602832