Push–Pull Stilbene: Visible Light Activated Photoremovable Protecting Group for Alcohols and Carboxylic Acids with Fluorescence Reporting Employed for Drug Delivery

For the first time we have utilized push–pull stilbene as a visible light activated photoremovable protecting group (PRPG) for the uncaging of alcohols and carboxylic acids. The PRPG efficiently release caged molecules with good photochemical quantum yield. It is capable of monitoring the release in...

Full description

Saved in:
Bibliographic Details
Published in:Organic letters 2019-05, Vol.21 (9), p.2968-2972
Main Authors: Paul, Amrita, Biswas, Angana, Sinha, Sreyashi, Shah, Sk. Sheriff, Bera, Manoranjan, Mandal, Mahitosh, Singh, N. D. Pradeep
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:For the first time we have utilized push–pull stilbene as a visible light activated photoremovable protecting group (PRPG) for the uncaging of alcohols and carboxylic acids. The PRPG efficiently release caged molecules with good photochemical quantum yield. It is capable of monitoring the release in real time owing to its fluorescence “turn on” phenomenon upon photorelease in polar medium. The efficient photorelease and real time monitoring abilities of push–pull stilbene were employed for in vitro drug delivery.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.9b00124