Graphene oxide incorporated polycaprolactone/chitosan/collagen electrospun scaffold: Enhanced osteogenic properties for bone tissue engineering

This in vitro study aimed to evaluate the physicochemical and biological activity of the polycaprolactone/chitosan/collagen scaffolds incorporated with 0, 0.5, 3, and 6 wt% of graphene oxide (GO). Using standard tests and MG‐63 cells, the characteristics of scaffolds were evaluated, and the behavior...

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Bibliographic Details
Published in:Artificial organs 2019-10, Vol.43 (10), p.E264-E281
Main Authors: Aidun, Amir, Safaei Firoozabady, Alireza, Moharrami, Mohammad, Ahmadi, Ali, Haghighipour, Nooshin, Bonakdar, Shahin, Faghihi, Shahab
Format: Article
Language:English
Subjects:
Biocompatible Materials - chemistry
Biological activity
Biomedical materials
Cell adhesion
Cell Line
Chitosan
Chitosan - chemistry
Collagen
Collagen - chemistry
electrospinning
Graphene
graphene oxide
Graphite - chemistry
guided bone regeneration
Humans
Materials Testing
Nanofibers
Nanofibers - chemistry
Osteoblasts
Osteoblasts - cytology
Osteogenesis
osteogenic property
Polycaprolactone
Polyesters - chemistry
Scaffolds
Tissue Engineering
Tissue Scaffolds - chemistry
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Summary:This in vitro study aimed to evaluate the physicochemical and biological activity of the polycaprolactone/chitosan/collagen scaffolds incorporated with 0, 0.5, 3, and 6 wt% of graphene oxide (GO). Using standard tests and MG‐63 cells, the characteristics of scaffolds were evaluated, and the behavior of osteoblasts were simulated, respectively. A non‐significant decrease in nanofibers diameter was noted in scaffolds with a higher ratio of GO. The hydrophilicity and bioactivity of the scaffold surface, as well as cell attachment and proliferation, increased in correspondence to an increase in GO. The higher ratio of GO also improved the osteogenesis activity. GO increased the degradation rate, but it was negligible and seemed not enough to endanger stability. Modifying the scaffolds with GO did not make a significant change to the antibacterial effect.
ISSN:0160-564X
1525-1594
DOI:10.1111/aor.13474