Value of blood oxygenation level-dependent MRI for predicting clinical outcomes in uterine cervical cancer treated with concurrent chemoradiotherapy

Objectives To investigate the value of blood oxygenation level-dependent (BOLD) MRI as a predictor of clinical outcomes in cervical cancer patients treated with concurrent chemoradiotherapy (CCRT). Method Enrolled 92 patients with stage IB2–IVB cervical cancer who received CCRT underwent 3-T BOLD MR...

Full description

Saved in:
Bibliographic Details
Published in:European radiology 2019-11, Vol.29 (11), p.6256-6265
Main Authors: Lee, Jiyeong, Kim, Chan Kyo, Gu, Kyo-won, Park, Won
Format: Article
Language:English
Subjects:
Adult
Aged
Antineoplastic Agents - therapeutic use
Blood
Cancer
Cervical cancer
Cervix
Chemoradiotherapy
Chemoradiotherapy - methods
Chemotherapy
Clinical outcomes
Correlation coefficient
Correlation coefficients
Diagnostic Radiology
Disease Progression
Female
Functional magnetic resonance imaging
Human papillomavirus
Humans
Imaging
Internal Medicine
Interventional Radiology
Magnetic Resonance Imaging - methods
Medicine
Medicine & Public Health
Middle Aged
Multivariate Analysis
Neuroradiology
Oxygen - blood
Oxygenation
Patients
Prognosis
Proportional Hazards Models
Radiation therapy
Radiology
Regression analysis
Reliability analysis
Reliability aspects
Reproducibility of Results
Retrospective Studies
Squamous cell carcinoma
Survival
Tumors
Ultrasound
Urogenital
Uterine cancer
Uterine Cervical Neoplasms - blood
Uterine Cervical Neoplasms - diagnostic imaging
Uterine Cervical Neoplasms - therapy
Uterus
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives To investigate the value of blood oxygenation level-dependent (BOLD) MRI as a predictor of clinical outcomes in cervical cancer patients treated with concurrent chemoradiotherapy (CCRT). Method Enrolled 92 patients with stage IB2–IVB cervical cancer who received CCRT underwent 3-T BOLD MRI before treatment. The R2* value (rate of spin dephasing, s −1 ) was measured in the tumor. Cox regression analysis was used to evaluate the associations of imaging and clinical parameters with progression-free survival (PFS) and cancer-specific survival (CSS). Inter-reader reliability for the R2* measurements was evaluated using an intraclass correlation coefficient (ICC). Results Tumor R2* values were significantly different between patients with and without disease progression ( p  
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-019-06198-5