Acute phase proteins and biomarkers of oxidative status in feline spontaneous malignant mammary tumours

Acute phase proteins (APP) and biomarkers of oxidative status change in human and canine mammary tumours, however, they have not been studied in feline mammary tumours. The aims of this study were to investigate the APP and antioxidant responses in feline malignant mammary tumours, to evaluate their...

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Published in:Veterinary & comparative oncology 2019-09, Vol.17 (3), p.394-406
Main Authors: Vilhena, Hugo, Tvarijonaviciute, Asta, Cerón, José J., Figueira, Ana C., Miranda, Sónia, Ribeiro, Ana, Canadas, Ana, Dias‐Pereira, Patrícia, Rubio, Camila P., Franco, Lorena, Tecles, Fernando, Cabeças, Ricardo, Pastor, Josep, Silvestre‐Ferreira, Ana C.
Format: Article
Language:English
Subjects:
Acute-Phase Proteins - metabolism
Animals
antioxidants
Biomarkers, Tumor
butyrylcholinesterase
Cat Diseases - metabolism
Cats
Female
haptoglobin
insulin‐like growth factor1
Mammary Neoplasms, Animal - metabolism
Mammary Neoplasms, Animal - pathology
Oxidative Stress
serum amyloid a
Survival Rate
total antioxidant capacity
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Summary:Acute phase proteins (APP) and biomarkers of oxidative status change in human and canine mammary tumours, however, they have not been studied in feline mammary tumours. The aims of this study were to investigate the APP and antioxidant responses in feline malignant mammary tumours, to evaluate their relation with tumour features, and to assess their prognostic value. Serum amyloid A (SAA), haptoglobin (Hp), albumin, butyrylcholinesterase (BChE), insulin‐like growth factor1 (IGF1), paraoxonase1 (PON1), total serum thiols (Thiol), glutathione peroxidase (GPox) and total antioxidant capacity determined by different assays, including trolox equivalent antioxidant capacity assessed by two different methodologies (TEAC1/2), ferric reducing ability of plasma (FRAP), and cupric reducing antioxidant capacity (CUPRAC), were determined in serum of 50 queens with spontaneous mammary carcinomas and of 12 healthy female cats. At diagnosis, diseased queens presented significantly higher SAA and Hp, and lower albumin, BChE, GPox, TEAC1, TEAC2 and CUPRAC than controls. Different tumour features influenced concentrations of APP and antioxidants. Increases in serum Hp, and decreases in albumin, Thiol and FRAP were significantly associated with neoplastic vascular emboli, metastasis in regional lymph nodes and/or in distant organs. Distant metastasis development during the course of the disease was associated with increases in SAA and TEAC1. At diagnosis, decreased albumin was associated with a longer survival, and BChE
ISSN:1476-5810
1476-5829
DOI:10.1111/vco.12486