Role of two‐component regulatory systems in intracellular survival of Mycobacterium tuberculosis

The typical two‐component regulatory systems (TCSs), consisting of response regulator and histidine kinase, play a central role in survival of pathogenic bacteria under stress conditions such as nutrient starvation, hypoxia, and nitrosative stress. A total of 11 complete paired two‐component regulat...

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Bibliographic Details
Published in:Journal of cellular biochemistry 2019-08, Vol.120 (8), p.12197-12207
Main Authors: Li, Xue, Lv, Xi, Lin, Yanping, Zhen, Junfeng, Ruan, Cao, Duan, Wei, Li, Yue, Xie, Jianping
Format: Article
Language:English
Subjects:
Histidine
Histidine kinase
Hypoxia
Intracellular
intracellular survival
Kinases
Metabolism
Mycobacterium tuberculosis
Pathogenicity
Pathogens
response regulator
Signal transduction
Starvation
Survival
Transduction
Tuberculosis
two‐component systems
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Summary:The typical two‐component regulatory systems (TCSs), consisting of response regulator and histidine kinase, play a central role in survival of pathogenic bacteria under stress conditions such as nutrient starvation, hypoxia, and nitrosative stress. A total of 11 complete paired two‐component regulatory systems have been found in Mycobacterium tuberculosis, including a few isolated kinase and regulatory genes. Increasing evidence has shown that TCSs are closely associated with multiple physiological process like intracellular persistence, pathogenicity, and metabolism. This review gives the two‐component signal transduction systems in M. tuberculosis and their signal transduction roles in adaption to the environment. Increasing evidence has shown that TCSs are closely associated with multiple physiological process like intracellular persistence, pathogenicity, and metabolism. This review gives the two‐component signal transduction systems in Mycobacterium tuberculosis and their signal transduction roles in adaption to the environment.
ISSN:0730-2312
1097-4644
DOI:10.1002/jcb.28792