Incidence of lymphoma in HIV-HCV-infected patients. Modifications in function of the anti-hepatitis C virus therapy

• Published in: Annals of hematology 2019-08, Vol.98 (8), p.1953-1959
• Main Authors: Gutiérrez-Saborido, Daniel, Gutiérrez-Valencia, Alicia, González Domenech, Carmen María, López Ruz, Miguel Ángel, Raffo Márquez, Miguel, Omar, Mohamed, Girón-González, José Antonio
• Format: Article
• Language: English
• Subjects: Antiviral drugs; Hematology; Hepatitis; Hepatitis C; Lymphoma; Medicine; Medicine & Public Health; Oncology; Original Article
• ISSN: 0939-5555; 1432-0584
• DOI: 10.1007/s00277-019-03700-3

The change in the incidence of lymphomas in function of the presence or absence of sustained virological response after anti-hepatitis C therapy in a cohort of human immunodeficiency (HIV)-hepatitis C (HCV) viruses coinfected patients was analyzed. A prospective cohort of 755 HIV-HCV coinfected patients who received their first anti-HCV therapy, based on interferon + ribavirin schemas, was evaluated. Incidence and histologic types of lymphomas were analyzed in two periods: (1) before administration of anti-HCV therapy and (2) after anti-HCV therapy. The association between lymphoma incidence and demographic, HIV- (minimum CD4+ cell count and CD4+ cell count at diagnosis of lymphoma, antiretroviral therapy, maximal HIV load and HIV load at diagnosis of lymphoma) and HCV-related variables (HCV load, genotype, sustained viral response to anti-HCV therapy) were analyzed. A total of 13 lymphomas [incidence rate (95% confidence interval), 0.72 (0.33–1.11) × 1000 person-years, time from HIV diagnosis to lymphoma diagnosis (median, interquartile range), 15 (11–19) years] were diagnosed. Nine of them were non-Hodgkin and four Hodgkin lymphomas. The median CD4+ T cell count at diagnosis of lymphoma was 457/mm 3 , with only two cases with values lower than 200/mm 3 . The incidence rate of non-Hodgkin lymphomas was similar pre- and post-anti HCV therapy [0.33 (0.00–0.65) vs 0.68 (0.08–1.26) × 1000 person-years, respectively, p  > 0.05]. Patients with sustained virologic HCV response showed similar incidence rate of lymphomas than that of those without anti-HCV response. In conclusion, anti-HCV therapy does not modify the incidence rate of lymphomas in HIV-HCV coinfected patients.