Are there differences in basal thrombophilias and C-reactive protein between women with or without PCOS?

• Published in: Reproductive biomedicine online 2019-06, Vol.38 (6), p.1018-1026
• Main Authors: Sánchez-Ferrer, María L, Prieto-Sánchez, María T, Corbalán-Biyang, Shiana, Mendiola, Jaime, Adoamnei, Evdochia, Hernández-Peñalver, Ana I, Carmona-Barnosi, Ana, Salido-Fiérrez, Eduardo J, Torres-Cantero, Alberto M
• Format: Article
• Language: English
• Subjects: Basal thrombophilia; C-reactive protein; Hormones; Pcos subtypes; Polycystic ovary syndrome
• ISSN: 1472-6483; 1472-6491
• DOI: 10.1016/j.rbmo.2019.01.013

Polycystic ovary syndrome (PCOS) women have increased cardiovascular risks, although it is unclear whether the haemostatic system and coagulation contribute to that increased risk. Women attending the Gynecology Unit of the ‘Virgen de la Arrixaca’ University Hospital (Murcia, Spain) for routine gynaecological examinations between September 2014 and May 2016 were assessed for PCOS using the Rotterdam criteria (hyperandrogenism [H], oligo/amenorrhoea [O] and polycystic ovarian morphology [POM]) and were classified into four phenotypic. In total, 126 cases were identified and 159 control women were selected. All women underwent physical and gynaecological examinations, and blood tests between the second and fifth day of the menstrual cycle. Differences in hormonal, basal thrombophilia and metabolic parameters, and C-reactive protein (CRP) between PCOS and controls were analysed. After adjusting by BMI and age, PCOS women had higher LH (P