Are there differences in basal thrombophilias and C-reactive protein between women with or without PCOS?

Polycystic ovary syndrome (PCOS) women have increased cardiovascular risks, although it is unclear whether the haemostatic system and coagulation contribute to that increased risk. Women attending the Gynecology Unit of the ‘Virgen de la Arrixaca’ University Hospital (Murcia, Spain) for routine gyna...

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Published in:Reproductive biomedicine online 2019-06, Vol.38 (6), p.1018-1026
Main Authors: Sánchez-Ferrer, María L, Prieto-Sánchez, María T, Corbalán-Biyang, Shiana, Mendiola, Jaime, Adoamnei, Evdochia, Hernández-Peñalver, Ana I, Carmona-Barnosi, Ana, Salido-Fiérrez, Eduardo J, Torres-Cantero, Alberto M
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Language:English
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Basal thrombophilia
C-reactive protein
Hormones
Pcos subtypes
Polycystic ovary syndrome
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creator Sánchez-Ferrer, María L
Prieto-Sánchez, María T
Corbalán-Biyang, Shiana
Mendiola, Jaime
Adoamnei, Evdochia
Hernández-Peñalver, Ana I
Carmona-Barnosi, Ana
Salido-Fiérrez, Eduardo J
Torres-Cantero, Alberto M
description Polycystic ovary syndrome (PCOS) women have increased cardiovascular risks, although it is unclear whether the haemostatic system and coagulation contribute to that increased risk. Women attending the Gynecology Unit of the ‘Virgen de la Arrixaca’ University Hospital (Murcia, Spain) for routine gynaecological examinations between September 2014 and May 2016 were assessed for PCOS using the Rotterdam criteria (hyperandrogenism [H], oligo/amenorrhoea [O] and polycystic ovarian morphology [POM]) and were classified into four phenotypic. In total, 126 cases were identified and 159 control women were selected. All women underwent physical and gynaecological examinations, and blood tests between the second and fifth day of the menstrual cycle. Differences in hormonal, basal thrombophilia and metabolic parameters, and C-reactive protein (CRP) between PCOS and controls were analysed. After adjusting by BMI and age, PCOS women had higher LH (P 
doi_str_mv 10.1016/j.rbmo.2019.01.013
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Women attending the Gynecology Unit of the ‘Virgen de la Arrixaca’ University Hospital (Murcia, Spain) for routine gynaecological examinations between September 2014 and May 2016 were assessed for PCOS using the Rotterdam criteria (hyperandrogenism [H], oligo/amenorrhoea [O] and polycystic ovarian morphology [POM]) and were classified into four phenotypic. In total, 126 cases were identified and 159 control women were selected. All women underwent physical and gynaecological examinations, and blood tests between the second and fifth day of the menstrual cycle. Differences in hormonal, basal thrombophilia and metabolic parameters, and C-reactive protein (CRP) between PCOS and controls were analysed. After adjusting by BMI and age, PCOS women had higher LH (P &lt; 0.001), testosterone (P &lt; 0.001), free testosterone (P = 0.01) and anti-Müllerian hormone (P &lt; 0.001) and lower FSH (P = 0.03) compared with controls, whereas sex hormone-binding globulin was no different. Cases showed significantly higher protein S, glucose, insulin and insulin resistance (HOMA-IR) compared with controls (P &lt; 0.05). There were no differences in protein C levels, antithrombin III, prothrombin time, homocysteine, D-dimer, factor V Leyden, prothrombin G20210A polymorphism or CRP. The H+O phenotype showed the poorest results for insulin and HOMA-IR (P = 0.04 and 0.05). The results suggest that there are no differences in the basal thrombophilias between women with and without PCOS. 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subjects Basal thrombophilia
C-reactive protein
Hormones
Pcos subtypes
Polycystic ovary syndrome
title Are there differences in basal thrombophilias and C-reactive protein between women with or without PCOS?
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