Palliative Resection of Primary Tumor in Metastatic Nonfunctioning Pancreatic Neuroendocrine Tumors

Whether primary tumor resection is beneficial in patients with metastatic nonfunctioning pancreatic neuroendocrine tumors (NF-pNETs) remains unclear. This study aimed to investigate whether palliative resection of primary tumor affected the survival of patients with stage IV NF-pNETs. We collected d...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of surgical research 2019-11, Vol.243, p.578-587
Main Authors: Ye, Hua, Xu, Hong Liu, Shen, Qijun, Zheng, Qi, Chen, Ping
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Female
Humans
Male
Metastases
Middle Aged
Neuroendocrine Tumors - mortality
Neuroendocrine Tumors - pathology
Neuroendocrine Tumors - surgery
NF-pNETs
Palliative
Palliative Care
Pancreas - pathology
Pancreatic Neoplasms - mortality
Pancreatic Neoplasms - pathology
Pancreatic Neoplasms - surgery
Primary tumor resection
Propensity Score
Retrospective Studies
SEER Program
Survival
United States - epidemiology
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Whether primary tumor resection is beneficial in patients with metastatic nonfunctioning pancreatic neuroendocrine tumors (NF-pNETs) remains unclear. This study aimed to investigate whether palliative resection of primary tumor affected the survival of patients with stage IV NF-pNETs. We collected data from patients with stage IV NF-pNET registered in the Surveillance, Epidemiology, and End Results database from 2004 to 2015. Risk-adjusted Cox proportional hazard regression analysis and propensity score–matched analysis were used to analyze overall survival (OS) and cancer-specific survival (CSS) of patients. In total, 1974 stage IV NF-pNETs patients were identified, of whom 392 (19.9%) received palliative primary tumor resection. The latter exhibited significantly prolonged OS (hazard ratio = 2.514, 95% confidence interval: 2.081-3.037, P 
ISSN:0022-4804
1095-8673
DOI:10.1016/j.jss.2019.04.002