Proof of Concept: Very Rapid Tidal Breathing Nasal Nitric Oxide Sampling Discriminates Primary Ciliary Dyskinesia from Healthy Subjects

Introduction Nasal nitric oxide (nNO) is extremely low in individuals with primary ciliary dyskinesia (PCD) and is recommended as part of early workup. We investigated whether tidal breathing sampling for a few seconds was as discriminative between PCD and healthy controls (HC) as conventional tidal...

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Bibliographic Details
Published in:Lung 2019-04, Vol.197 (2), p.209-216
Main Authors: Holgersen, Mathias G., Marthin, June K., Nielsen, Kim G.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Airway Biology
Biomarkers - metabolism
Breath Tests
Breathing
Case-Control Studies
Child
Children
Ciliary Motility Disorders - diagnosis
Ciliary Motility Disorders - metabolism
Ciliary Motility Disorders - physiopathology
Diagnosis
Feasibility Studies
Female
Humans
Infants
Male
Medicine
Medicine & Public Health
Middle Aged
Movement disorders
Nitric oxide
Nitric Oxide - metabolism
Nose
Patients
Pneumology/Respiratory System
Predictive Value of Tests
Pressure
Primary ciliary dyskinesia
Proof of Concept Study
Reproducibility of Results
Respiration
Risk factors
Sampling
Suction
Time Factors
Vacuum
Young Adult
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Summary:Introduction Nasal nitric oxide (nNO) is extremely low in individuals with primary ciliary dyskinesia (PCD) and is recommended as part of early workup. We investigated whether tidal breathing sampling for a few seconds was as discriminative between PCD and healthy controls (HC) as conventional tidal breathing sampling (cTB-nNO) for 20–30 s. Methods We performed very rapid sampling of tidal breathing (vrTB-nNO) for 2, 4 and 6 s, respectively. Vacuum sampling with applied negative pressure (vrTB-nNO vac ; negative pressure was applied by pinching the sampling tube) for
ISSN:0341-2040
1432-1750
DOI:10.1007/s00408-019-00202-x