LncRNA AWPPH and miRNA‐21 regulates cancer cell proliferation and chemosensitivity in triple‐negative breast cancer by interacting with each other

Long–non‐coding RNAs (lncRNA) AWPPH promotes the progression of liver and bladder cancer, indicating its oncogenic role. The current study aimed to explore the involvement of AWPPH in triple‐negative breast cancer (TNBC). In the current study, we found that plasma levels of lncRNA AWPPH and microRNA...

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Bibliographic Details
Published in:Journal of cellular biochemistry 2019-09, Vol.120 (9), p.14860-14866
Main Authors: Liu, Ai‐Na, Qu, Hua‐Jun, Gong, Wen‐Jing, Xiang, Jin‐Yu, Yang, Miao‐Miao, Zhang, Wei
Format: Article
Language:English
Subjects:
Bladder
Bladder cancer
Breast cancer
Carboplatin
Cell growth
Cell proliferation
Cell viability
chemosensitivity
Liver cancer
long–non‐coding RNA AWPPH
MicroRNAs
microRNA‐21
miRNA
Plasma levels
Ribonucleic acid
RNA
RNA-mediated interference
siRNA
triple‐negative breast cancer
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Summary:Long–non‐coding RNAs (lncRNA) AWPPH promotes the progression of liver and bladder cancer, indicating its oncogenic role. The current study aimed to explore the involvement of AWPPH in triple‐negative breast cancer (TNBC). In the current study, we found that plasma levels of lncRNA AWPPH and microRNA‐21 (miRNA‐21) were upregulated in patients with TNBC than in healthy controls, and the upregulation of plasma lncRNA AWPPH and miRNA‐21 distinguished early‐stage patients with TNBC from healthy controls. Plasma levels of lncRNA AWPPH and miRNA‐21 were significantly and positively correlated in both patients with TNBC and healthy controls. LncRNA AWPPH and miRNA‐21 overexpression led to promoted cancer cells proliferation and improved cancer cell viability under carboplatin treatment, while lncRNA AWPPH small interfering RNA (siRNA) silencing played an opposite role. In addition, miRNA‐21 overexpression attenuated the effects of lncRNA AWPPH siRNA silencing on of cancer cell behaviors. LncRNA AWPPH overexpression led to upregulated miRNA‐21 in TNBC cells, while miRNA‐21 overexpression also led to significantly upregulated lncRNA AWPPH expression. Therefore, lncRNA AWPPH and miRNA‐21 may regulate cancer cell proliferation and chemosensitivity in TNBC by interacting with each other. Long–non‐coding RNA (lncRNA) AWPPH and microRNA‐21 (miRNA‐21) were both upregulated in triple‐negative breast cancer (TNBC). LncRNA AWPPH and miRNA‐21 may regulate cancer cell proliferation and chemosensitivity in TNBC by interacting with each other.
ISSN:0730-2312
1097-4644
DOI:10.1002/jcb.28747