Efficacy and safety of direct‐acting antivirals for hepatitis C in the elderly: A systematic review and meta‐analysis

Background&Aims Since the introduction of direct‐acting antivirals (DAAs) several studies have reported high efficacy and safety in Hepatitis C infected patients, even in those earlier considered difficult‐to‐treat. We aimed to assess the efficacy and safety of DAA therapy in elderly patients. M...

Full description

Saved in:
Bibliographic Details
Published in:Liver international 2019-09, Vol.39 (9), p.1652-1660
Main Authors: Mücke, Marcus M., Herrmann, Eva, Mücke, Victoria T., Graf, Christiana, Zeuzem, Stefan, Vermehren, Johannes
Format: Article
Language:English
Subjects:
Age
Anemia
Antiviral agents
Cost analysis
direct‐acting antiviral therapy
Economic analysis
Effectiveness
Geriatrics
Hepatitis
Hepatitis C
Hepatitis C virus
Liver diseases
Meta-analysis
old age
Older people
Quality assessment
Ribavirin
Risk assessment
Safety
Subgroups
Therapy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background&Aims Since the introduction of direct‐acting antivirals (DAAs) several studies have reported high efficacy and safety in Hepatitis C infected patients, even in those earlier considered difficult‐to‐treat. We aimed to assess the efficacy and safety of DAA therapy in elderly patients. Methods The PubMed MEDLINE, Embase and Cochrane databases were searched through July 2018. Two independent researchers extracted data and assessed the quality and risk of bias. Risk ratios (RRs) were pooled using random effects models. The primary outcome was efficacy of DAA therapy assessed by the RR for non‐sustained virologic response (SVR) among patients aged
ISSN:1478-3223
1478-3231
DOI:10.1111/liv.14126