Comparison of conventional, diffusion, and perfusion MRI between infratentorial ganglioglioma and pilocytic astrocytoma

Background The differentiation of infratentorial ganglioglioma and pilocytic astrocytoma may be therapeutically relevant, which is sometimes challenging to both pathologists and neuroradiologists. Purpose To evaluate the conventional magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI)...

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Bibliographic Details
Published in:Acta radiologica (1987) 2019-12, Vol.60 (12), p.1687-1694
Main Authors: She, De-jun, Lu, Yi-ping, Xiong, Ji, Cao, Dai-rong, Geng, Dao-ying, Yin, Bo
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Astrocytoma - diagnostic imaging
Brain - diagnostic imaging
Brain Neoplasms - diagnostic imaging
Child
Child, Preschool
Diagnosis, Differential
Diffusion Magnetic Resonance Imaging
Female
Ganglioglioma - diagnostic imaging
Humans
Magnetic Resonance Imaging - methods
Male
Middle Aged
Perfusion Imaging
Retrospective Studies
Young Adult
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Summary:Background The differentiation of infratentorial ganglioglioma and pilocytic astrocytoma may be therapeutically relevant, which is sometimes challenging to both pathologists and neuroradiologists. Purpose To evaluate the conventional magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI), and dynamic susceptibility contrast-enhanced perfusion weighted imaging (DSC-PWI) features of infratentorial ganglioglioma compared with pilocytic astrocytoma. Material and Methods This retrospective study enrolled 12 patients with infratentorial ganglioglioma and 61 patients with pilocytic astrocytoma who underwent MRI before surgery. DSC-PWI was performed in 20 patients (4 gangliogliomas, 16 pilocytic astrocytoma). Demographics, conventional imaging characteristics (tumor location, margin, cystic change, enhancement, peritumoral edema, and ipsilateral cerebellar atrophy), rADCmin, and rCBVmax ratio were compared. The optimum threshold, sensitivity, and specificity for rADCmin and rCBVmax ratios were determined. Results Infratentorial ganglioglioma appeared similar to pilocytic astrocytoma but was more likely to have an ill-defined margin (P = 0.035), ipsilateral cerebellar atrophy (P 
ISSN:0284-1851
1600-0455
DOI:10.1177/0284185119845088