Loading…
Comparison of conventional, diffusion, and perfusion MRI between infratentorial ganglioglioma and pilocytic astrocytoma
Background The differentiation of infratentorial ganglioglioma and pilocytic astrocytoma may be therapeutically relevant, which is sometimes challenging to both pathologists and neuroradiologists. Purpose To evaluate the conventional magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI)...
Saved in:
| Published in: | Acta radiologica (1987) 2019-12, Vol.60 (12), p.1687-1694 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c337t-aff5d93161243c944ac1b956a1d3b2767e6a72bbf16d34612faedc9b7baa774a3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c337t-aff5d93161243c944ac1b956a1d3b2767e6a72bbf16d34612faedc9b7baa774a3 |
| container_end_page | 1694 |
| container_issue | 12 |
| container_start_page | 1687 |
| container_title | Acta radiologica (1987) |
| container_volume | 60 |
| creator | She, De-jun Lu, Yi-ping Xiong, Ji Cao, Dai-rong Geng, Dao-ying Yin, Bo |
| description | Background
The differentiation of infratentorial ganglioglioma and pilocytic astrocytoma may be therapeutically relevant, which is sometimes challenging to both pathologists and neuroradiologists.
Purpose
To evaluate the conventional magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI), and dynamic susceptibility contrast-enhanced perfusion weighted imaging (DSC-PWI) features of infratentorial ganglioglioma compared with pilocytic astrocytoma.
Material and Methods
This retrospective study enrolled 12 patients with infratentorial ganglioglioma and 61 patients with pilocytic astrocytoma who underwent MRI before surgery. DSC-PWI was performed in 20 patients (4 gangliogliomas, 16 pilocytic astrocytoma). Demographics, conventional imaging characteristics (tumor location, margin, cystic change, enhancement, peritumoral edema, and ipsilateral cerebellar atrophy), rADCmin, and rCBVmax ratio were compared. The optimum threshold, sensitivity, and specificity for rADCmin and rCBVmax ratios were determined.
Results
Infratentorial ganglioglioma appeared similar to pilocytic astrocytoma but was more likely to have an ill-defined margin (P = 0.035), ipsilateral cerebellar atrophy (P |
| doi_str_mv | 10.1177/0284185119845088 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2216774267</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0284185119845088</sage_id><sourcerecordid>2216774267</sourcerecordid><originalsourceid>FETCH-LOGICAL-c337t-aff5d93161243c944ac1b956a1d3b2767e6a72bbf16d34612faedc9b7baa774a3</originalsourceid><addsrcrecordid>eNp1kEFr3DAQhUVISLbb3nsqOuYQNxrJluxjWdI2kBIIydmMZWlRsKWNZDfsv6-M0xwKPQwzw_veOzxCPgP7CqDUNeN1CXUF0NRlxer6hGxAMlawsqpOyWaRi0W_IB9SemYMuKrgnFwIYIJLXm3I6y6MB4wuBU-DpTr438ZPLngcrmjvrJ1Tfq4o-p4eTFxf-uvhlnZmejXGU-dtxCmbQnQ40D36_eDCMiOuNjcEfZycppimuJxZ-UjOLA7JfHrbW_L0_eZx97O4u_9xu_t2V2gh1FSgtVXfCJDAS6GbskQNXVNJhF50XEllJCredRZkL8pMWTS9bjrVISpVotiSyzX3EMPLbNLUji5pMwzoTZhTyznIDHKpMspWVMeQUjS2PUQ3Yjy2wNql7vbfurPly1v63I2mfzf87TcDxQok3Jv2OcwxF5v-H_gHJoaKEw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2216774267</pqid></control><display><type>article</type><title>Comparison of conventional, diffusion, and perfusion MRI between infratentorial ganglioglioma and pilocytic astrocytoma</title><source>Sage Journals Online</source><creator>She, De-jun ; Lu, Yi-ping ; Xiong, Ji ; Cao, Dai-rong ; Geng, Dao-ying ; Yin, Bo</creator><creatorcontrib>She, De-jun ; Lu, Yi-ping ; Xiong, Ji ; Cao, Dai-rong ; Geng, Dao-ying ; Yin, Bo</creatorcontrib><description>Background
The differentiation of infratentorial ganglioglioma and pilocytic astrocytoma may be therapeutically relevant, which is sometimes challenging to both pathologists and neuroradiologists.
Purpose
To evaluate the conventional magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI), and dynamic susceptibility contrast-enhanced perfusion weighted imaging (DSC-PWI) features of infratentorial ganglioglioma compared with pilocytic astrocytoma.
Material and Methods
This retrospective study enrolled 12 patients with infratentorial ganglioglioma and 61 patients with pilocytic astrocytoma who underwent MRI before surgery. DSC-PWI was performed in 20 patients (4 gangliogliomas, 16 pilocytic astrocytoma). Demographics, conventional imaging characteristics (tumor location, margin, cystic change, enhancement, peritumoral edema, and ipsilateral cerebellar atrophy), rADCmin, and rCBVmax ratio were compared. The optimum threshold, sensitivity, and specificity for rADCmin and rCBVmax ratios were determined.
Results
Infratentorial ganglioglioma appeared similar to pilocytic astrocytoma but was more likely to have an ill-defined margin (P = 0.035), ipsilateral cerebellar atrophy (P < 0.001), lower rADCmin ratio (1.24 ± 0.27 vs. 2.04 ± 0.46, P < 0.001), and higher rCBVmax ratio (3.05 ± 1.12 vs. 1.64 ± 0.39; P = 0.008). The threshold values ≤1.66 for rADCmin ratio provide sensitivity and specificity of 91.67% and 77.05%, respectively, for discriminating ganglioglioma from pilocytic astrocytoma. The optimal threshold value for rCBVmax ratio was >1.64.
Conclusion
Conventional MRI, DWI, and DSC-PWI can help to differentiate infratentorial ganglioglioma from pilocytic astrocytoma. DWI offers optimal sensitivity.</description><identifier>ISSN: 0284-1851</identifier><identifier>EISSN: 1600-0455</identifier><identifier>DOI: 10.1177/0284185119845088</identifier><identifier>PMID: 31032625</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adolescent ; Adult ; Aged ; Astrocytoma - diagnostic imaging ; Brain - diagnostic imaging ; Brain Neoplasms - diagnostic imaging ; Child ; Child, Preschool ; Diagnosis, Differential ; Diffusion Magnetic Resonance Imaging ; Female ; Ganglioglioma - diagnostic imaging ; Humans ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Perfusion Imaging ; Retrospective Studies ; Young Adult</subject><ispartof>Acta radiologica (1987), 2019-12, Vol.60 (12), p.1687-1694</ispartof><rights>The Foundation Acta Radiologica 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-aff5d93161243c944ac1b956a1d3b2767e6a72bbf16d34612faedc9b7baa774a3</citedby><cites>FETCH-LOGICAL-c337t-aff5d93161243c944ac1b956a1d3b2767e6a72bbf16d34612faedc9b7baa774a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923,79134</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31032625$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>She, De-jun</creatorcontrib><creatorcontrib>Lu, Yi-ping</creatorcontrib><creatorcontrib>Xiong, Ji</creatorcontrib><creatorcontrib>Cao, Dai-rong</creatorcontrib><creatorcontrib>Geng, Dao-ying</creatorcontrib><creatorcontrib>Yin, Bo</creatorcontrib><title>Comparison of conventional, diffusion, and perfusion MRI between infratentorial ganglioglioma and pilocytic astrocytoma</title><title>Acta radiologica (1987)</title><addtitle>Acta Radiol</addtitle><description>Background
The differentiation of infratentorial ganglioglioma and pilocytic astrocytoma may be therapeutically relevant, which is sometimes challenging to both pathologists and neuroradiologists.
Purpose
To evaluate the conventional magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI), and dynamic susceptibility contrast-enhanced perfusion weighted imaging (DSC-PWI) features of infratentorial ganglioglioma compared with pilocytic astrocytoma.
Material and Methods
This retrospective study enrolled 12 patients with infratentorial ganglioglioma and 61 patients with pilocytic astrocytoma who underwent MRI before surgery. DSC-PWI was performed in 20 patients (4 gangliogliomas, 16 pilocytic astrocytoma). Demographics, conventional imaging characteristics (tumor location, margin, cystic change, enhancement, peritumoral edema, and ipsilateral cerebellar atrophy), rADCmin, and rCBVmax ratio were compared. The optimum threshold, sensitivity, and specificity for rADCmin and rCBVmax ratios were determined.
Results
Infratentorial ganglioglioma appeared similar to pilocytic astrocytoma but was more likely to have an ill-defined margin (P = 0.035), ipsilateral cerebellar atrophy (P < 0.001), lower rADCmin ratio (1.24 ± 0.27 vs. 2.04 ± 0.46, P < 0.001), and higher rCBVmax ratio (3.05 ± 1.12 vs. 1.64 ± 0.39; P = 0.008). The threshold values ≤1.66 for rADCmin ratio provide sensitivity and specificity of 91.67% and 77.05%, respectively, for discriminating ganglioglioma from pilocytic astrocytoma. The optimal threshold value for rCBVmax ratio was >1.64.
Conclusion
Conventional MRI, DWI, and DSC-PWI can help to differentiate infratentorial ganglioglioma from pilocytic astrocytoma. DWI offers optimal sensitivity.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Astrocytoma - diagnostic imaging</subject><subject>Brain - diagnostic imaging</subject><subject>Brain Neoplasms - diagnostic imaging</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Diagnosis, Differential</subject><subject>Diffusion Magnetic Resonance Imaging</subject><subject>Female</subject><subject>Ganglioglioma - diagnostic imaging</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Perfusion Imaging</subject><subject>Retrospective Studies</subject><subject>Young Adult</subject><issn>0284-1851</issn><issn>1600-0455</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kEFr3DAQhUVISLbb3nsqOuYQNxrJluxjWdI2kBIIydmMZWlRsKWNZDfsv6-M0xwKPQwzw_veOzxCPgP7CqDUNeN1CXUF0NRlxer6hGxAMlawsqpOyWaRi0W_IB9SemYMuKrgnFwIYIJLXm3I6y6MB4wuBU-DpTr438ZPLngcrmjvrJ1Tfq4o-p4eTFxf-uvhlnZmejXGU-dtxCmbQnQ40D36_eDCMiOuNjcEfZycppimuJxZ-UjOLA7JfHrbW_L0_eZx97O4u_9xu_t2V2gh1FSgtVXfCJDAS6GbskQNXVNJhF50XEllJCredRZkL8pMWTS9bjrVISpVotiSyzX3EMPLbNLUji5pMwzoTZhTyznIDHKpMspWVMeQUjS2PUQ3Yjy2wNql7vbfurPly1v63I2mfzf87TcDxQok3Jv2OcwxF5v-H_gHJoaKEw</recordid><startdate>201912</startdate><enddate>201912</enddate><creator>She, De-jun</creator><creator>Lu, Yi-ping</creator><creator>Xiong, Ji</creator><creator>Cao, Dai-rong</creator><creator>Geng, Dao-ying</creator><creator>Yin, Bo</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201912</creationdate><title>Comparison of conventional, diffusion, and perfusion MRI between infratentorial ganglioglioma and pilocytic astrocytoma</title><author>She, De-jun ; Lu, Yi-ping ; Xiong, Ji ; Cao, Dai-rong ; Geng, Dao-ying ; Yin, Bo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-aff5d93161243c944ac1b956a1d3b2767e6a72bbf16d34612faedc9b7baa774a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Astrocytoma - diagnostic imaging</topic><topic>Brain - diagnostic imaging</topic><topic>Brain Neoplasms - diagnostic imaging</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Diagnosis, Differential</topic><topic>Diffusion Magnetic Resonance Imaging</topic><topic>Female</topic><topic>Ganglioglioma - diagnostic imaging</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Perfusion Imaging</topic><topic>Retrospective Studies</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>She, De-jun</creatorcontrib><creatorcontrib>Lu, Yi-ping</creatorcontrib><creatorcontrib>Xiong, Ji</creatorcontrib><creatorcontrib>Cao, Dai-rong</creatorcontrib><creatorcontrib>Geng, Dao-ying</creatorcontrib><creatorcontrib>Yin, Bo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta radiologica (1987)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>She, De-jun</au><au>Lu, Yi-ping</au><au>Xiong, Ji</au><au>Cao, Dai-rong</au><au>Geng, Dao-ying</au><au>Yin, Bo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of conventional, diffusion, and perfusion MRI between infratentorial ganglioglioma and pilocytic astrocytoma</atitle><jtitle>Acta radiologica (1987)</jtitle><addtitle>Acta Radiol</addtitle><date>2019-12</date><risdate>2019</risdate><volume>60</volume><issue>12</issue><spage>1687</spage><epage>1694</epage><pages>1687-1694</pages><issn>0284-1851</issn><eissn>1600-0455</eissn><abstract>Background
The differentiation of infratentorial ganglioglioma and pilocytic astrocytoma may be therapeutically relevant, which is sometimes challenging to both pathologists and neuroradiologists.
Purpose
To evaluate the conventional magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI), and dynamic susceptibility contrast-enhanced perfusion weighted imaging (DSC-PWI) features of infratentorial ganglioglioma compared with pilocytic astrocytoma.
Material and Methods
This retrospective study enrolled 12 patients with infratentorial ganglioglioma and 61 patients with pilocytic astrocytoma who underwent MRI before surgery. DSC-PWI was performed in 20 patients (4 gangliogliomas, 16 pilocytic astrocytoma). Demographics, conventional imaging characteristics (tumor location, margin, cystic change, enhancement, peritumoral edema, and ipsilateral cerebellar atrophy), rADCmin, and rCBVmax ratio were compared. The optimum threshold, sensitivity, and specificity for rADCmin and rCBVmax ratios were determined.
Results
Infratentorial ganglioglioma appeared similar to pilocytic astrocytoma but was more likely to have an ill-defined margin (P = 0.035), ipsilateral cerebellar atrophy (P < 0.001), lower rADCmin ratio (1.24 ± 0.27 vs. 2.04 ± 0.46, P < 0.001), and higher rCBVmax ratio (3.05 ± 1.12 vs. 1.64 ± 0.39; P = 0.008). The threshold values ≤1.66 for rADCmin ratio provide sensitivity and specificity of 91.67% and 77.05%, respectively, for discriminating ganglioglioma from pilocytic astrocytoma. The optimal threshold value for rCBVmax ratio was >1.64.
Conclusion
Conventional MRI, DWI, and DSC-PWI can help to differentiate infratentorial ganglioglioma from pilocytic astrocytoma. DWI offers optimal sensitivity.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>31032625</pmid><doi>10.1177/0284185119845088</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0284-1851 |
| ispartof | Acta radiologica (1987), 2019-12, Vol.60 (12), p.1687-1694 |
| issn | 0284-1851 1600-0455 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2216774267 |
| source | Sage Journals Online |
| subjects | Adolescent Adult Aged Astrocytoma - diagnostic imaging Brain - diagnostic imaging Brain Neoplasms - diagnostic imaging Child Child, Preschool Diagnosis, Differential Diffusion Magnetic Resonance Imaging Female Ganglioglioma - diagnostic imaging Humans Magnetic Resonance Imaging - methods Male Middle Aged Perfusion Imaging Retrospective Studies Young Adult |
| title | Comparison of conventional, diffusion, and perfusion MRI between infratentorial ganglioglioma and pilocytic astrocytoma |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T12%3A38%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20of%20conventional,%20diffusion,%20and%20perfusion%20MRI%20between%20infratentorial%20ganglioglioma%20and%20pilocytic%20astrocytoma&rft.jtitle=Acta%20radiologica%20(1987)&rft.au=She,%20De-jun&rft.date=2019-12&rft.volume=60&rft.issue=12&rft.spage=1687&rft.epage=1694&rft.pages=1687-1694&rft.issn=0284-1851&rft.eissn=1600-0455&rft_id=info:doi/10.1177/0284185119845088&rft_dat=%3Cproquest_cross%3E2216774267%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c337t-aff5d93161243c944ac1b956a1d3b2767e6a72bbf16d34612faedc9b7baa774a3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2216774267&rft_id=info:pmid/31032625&rft_sage_id=10.1177_0284185119845088&rfr_iscdi=true |