Predictors of Transition to Psychosis in Individuals at Clinical High Risk

Purpose of Review Current research is examining predictors of the transition to psychosis in youth who are at clinical high risk based on attenuated psychotic symptoms (APS). Determining predictors of the development of psychosis is important for an improved understanding of mechanisms as well as th...

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Bibliographic Details
Published in:Current psychiatry reports 2019-06, Vol.21 (6), p.39-39, Article 39
Main Authors: Addington, Jean, Farris, Megan, Stowkowy, Jacqueline, Santesteban-Echarri, Olga, Metzak, Paul, Kalathil, Mohammed Shakeel
Format: Article
Language:English
Subjects:
Cognition
Humans
Medicine
Medicine & Public Health
Precision Medicine in Psychiatry (S Kennedy
Prognosis
Psychiatry
Psychosis
Psychotic Disorders - diagnosis
Psychotic Disorders - psychology
Risk Assessment
Risk Factors
Section Editor
Topical Collection on Precision Medicine in Psychiatry
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Summary:Purpose of Review Current research is examining predictors of the transition to psychosis in youth who are at clinical high risk based on attenuated psychotic symptoms (APS). Determining predictors of the development of psychosis is important for an improved understanding of mechanisms as well as the development of preventative strategies. The purpose is to review the most recent literature identifying predictors of the transition to psychosis in those who are already assessed as being at risk. Recent Findings Multidomain models, in particular, integrated models of symptoms, social functioning, and cognition variables, achieve better predictive performance than individual factors. There are many methodological issues; however, several solutions have now been described in the literature. Summary For youth who already have APS, predicting who may go on to later develop psychosis is possible. Several studies are underway in large consortiums that may overcome some of the methodological concerns and develop improved means of prediction.
ISSN:1523-3812
1535-1645
DOI:10.1007/s11920-019-1027-y