Osteoarthritis

Osteoarthritis is a leading cause of disability and source of societal cost in older adults. With an ageing and increasingly obese population, this syndrome is becoming even more prevalent than in previous decades. In recent years, we have gained important insights into the cause and pathogenesis of...

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Bibliographic Details
Published in:The Lancet (British edition) 2019-04, Vol.393 (10182), p.1745-1759
Main Authors: Hunter, David J, Bierma-Zeinstra, Sita
Format: Article
Language:English
Subjects:
Adults
Aging
Arthritis
Biocompatibility
Clinical decision making
Core loss
Decision making
Diagnosis
Knee
Management
Medical diagnosis
Middle age
Older people
Osteoarthritis
Pain
Pathogenesis
Public health
Surgery
Weight control
Weight loss
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Summary:Osteoarthritis is a leading cause of disability and source of societal cost in older adults. With an ageing and increasingly obese population, this syndrome is becoming even more prevalent than in previous decades. In recent years, we have gained important insights into the cause and pathogenesis of pain in osteoarthritis. The diagnosis of osteoarthritis is clinically based despite the widespread overuse of imaging methods. Management should be tailored to the presenting individual and focus on core treatments, including self-management and education, exercise, and weight loss as relevant. Surgery should be reserved for those that have not responded appropriately to less invasive methods. Prevention and disease modification are areas being targeted by various research endeavours, which have indicated great potential thus far. This narrative Seminar provides an update on the pathogenesis, diagnosis, management, and future research on osteoarthritis for a clinical audience.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(19)30417-9