Porphyrin Nanocage‐Embedded Single‐Molecular Nanoparticles for Cancer Nanotheranostics

Single molecular nanoparticles (SMNPs) integrating imaging and therapeutic capabilities exhibit unparalleled advantages in cancer theranostics, ranging from excellent biocompatibility, high stability, prolonged blood lifetime to abundant tumor accumulation. Herein, we synthesize a sophisticated porp...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2019-06, Vol.58 (26), p.8799-8803
Main Authors: Yu, Guocan, Cen, Tian‐Yong, He, Zhimei, Wang, Shu‐Ping, Wang, Zhantong, Ying, Xin‐Wen, Li, Shijun, Jacobson, Orit, Wang, Sheng, Wang, Lei, Lin, Li‐Sen, Tian, Rui, Zhou, Zijian, Ni, Qianqian, Li, Xiaopeng, Chen, Xiaoyuan
Format: Article
Language:English
Subjects:
Ablation
Accumulation
Biocompatibility
Cancer
cancer treatment
Humans
imaging
Nanoparticles
Nanoparticles - chemistry
Nanotechnology - methods
nanotheranostics
Permeability
Photodynamic therapy
Photosensitization
Polyethylene glycol
Polyethylene terephthalate
Porphyrins - chemistry
Precision medicine
singlet oxygen
Theranostic Nanomedicine - methods
Tumors
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Summary:Single molecular nanoparticles (SMNPs) integrating imaging and therapeutic capabilities exhibit unparalleled advantages in cancer theranostics, ranging from excellent biocompatibility, high stability, prolonged blood lifetime to abundant tumor accumulation. Herein, we synthesize a sophisticated porphyrin nanocage that is further functionalized with twelve polyethylene glycol arms to prepare SMNPs (porSMNPs). The porphyrin nanocage embedded in porSMNPs can be utilized as a theranostic platform. PET imaging allows dynamic observation of the bio‐distribution of porSMNPs, confirming their excellent circulation time and preferential accumulation at the tumor site, which is attributed to the enhanced permeability and retention effect. Moreover, the cage structure significantly promotes the photosensitizing effect of porSMNs by inhibiting the π–π stacking interactions of the photosensitizers, ablating of the tumors without relapse by taking advantage of photodynamic therapy. Sophisticated porphyrin nanocages, which can be utilized as a functional platform to develop single molecular nanoparticles, were synthesized. The unique topological structure of the nanocages results in their excellent performance as cancer nanotheranostics, as demonstrated through applications in PET imaging and photodynamic therapy.
ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.201903277