Anti-inflammatory and antinociceptive effects of active ingredients in the essential oils from Gynura procumbens, a traditional medicine and a new and popular food material

Gynura procumbens is applied topically for the treatment of traumatic injuries in South China. This study was conducted to identify the active ingredients in the essential oils from Gynura procumbens (GPEO) by Gas Chromatography-Mass Spectrometer (GC–MS) and to elucidate the mechanisms underlying th...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2019-07, Vol.239, p.111916-111916, Article 111916
Main Authors: Huang, Xia-Ling, Li, Xiao-Jun, Qin, Qiu-Fang, Li, Yu-Sang, Zhang, Wei Kevin, Tang, He-Bin
Format: Article
Language:English
Subjects:
Analgesic
Analgesics - therapeutic use
Animals
Anti-Inflammatory
Anti-Inflammatory Agents - therapeutic use
Asteraceae
Cell Movement - drug effects
Cyclooxygenase-2
Edema - chemically induced
Edema - drug therapy
Essential oils
Food
Formaldehyde
Gynura procumbens
Hot Temperature - adverse effects
Male
Medicine, Chinese Traditional
Mice
Oils, Volatile - therapeutic use
Pain - chemically induced
Pain - drug therapy
Phytotherapy
RAW 264.7 Cells
Traditional medicine
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Summary:Gynura procumbens is applied topically for the treatment of traumatic injuries in South China. This study was conducted to identify the active ingredients in the essential oils from Gynura procumbens (GPEO) by Gas Chromatography-Mass Spectrometer (GC–MS) and to elucidate the mechanisms underlying the anti-inflammatory and antinociceptive effects in vivo and in vitro. A reduction in dswelling and pain were observed in mice treated with GPEO or its active ingredients (α-pinene, 3-carene, and limonene) compared with mice treated with a solvent control. GPEO or its three active ingredients had potent pharmacological effects on COX-2 overexpression and LPS-induced migration of Raw264.7 macrophages. All three ingredients inhibited nociceptive stimulus-induced inflammatory infiltrates and COX-2 overexpression, which could be responsible for the anti-inflammatory effect of GPEO. However, only 3-carene produced an antinociceptive effect. Consistent with the traditional usage in Southern China, GPEO may serve as a promising potent external therapeutic agent for the treatment of chronic pain. [Display omitted]
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2019.111916