A randomised controlled trial of phenylephrine and noradrenaline boluses for treatment of postspinal hypotension during elective caesarean section

Summary Phenylephrine is currently the vasopressor of choice during elective caesarean section, but it can cause reflex bradycardia. Noradrenaline, a potent α‐agonist and weak β‐agonist, may be associated with a lower incidence of bradycardia. However, comparative information is limited. This double...

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Bibliographic Details
Published in:Anaesthesia 2019-07, Vol.74 (7), p.850-855
Main Authors: Mohta, M., Garg, A., Chilkoti, G. T., Malhotra, R. K.
Format: Article
Language:English
Subjects:
Adult
Agonists
alpha‐agonist
anaesthesia
spinal
Anesthesia, Obstetrical - adverse effects
Anesthesia, Spinal - adverse effects
Blood pressure
Bradycardia
caesarean section
Cardiac arrhythmia
Cesarean Section
Double-Blind Method
Elective Surgical Procedures
Evidence-based medicine
Female
Fetuses
Heart rate
Humans
Hypertension
Hypotension
Hypotension - drug therapy
Hypotension - etiology
hypotension, treatment
Incidence
Infusions, Intravenous
Noradrenaline
Norepinephrine
Norepinephrine - administration & dosage
Norepinephrine - therapeutic use
pH effects
Phenylephrine
Phenylephrine - administration & dosage
Phenylephrine - therapeutic use
Placenta
Placental transfer
Pregnancy
Randomization
Statistical analysis
Statistical significance
Treatment Outcome
Vasoconstrictor Agents - administration & dosage
Vasoconstrictor Agents - therapeutic use
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Summary:Summary Phenylephrine is currently the vasopressor of choice during elective caesarean section, but it can cause reflex bradycardia. Noradrenaline, a potent α‐agonist and weak β‐agonist, may be associated with a lower incidence of bradycardia. However, comparative information is limited. This double‐blind randomised controlled trial compared the effects of 100 μg phenylephrine and 5 μg noradrenaline administered as boluses for the treatment of postspinal hypotension during elective caesarean section in women with an uncomplicated singleton pregnancy. Hypotension was defined as a decrease of ≥ 20% from baseline systolic arterial pressure, or an absolute value
ISSN:0003-2409
1365-2044
DOI:10.1111/anae.14675