The haemoglobin glycation index is associated with nonalcoholic fatty liver disease in healthy subjects

Objectives The hemoglobin glycation index (HGI) quantifies interindividual variations in glycated hemoglobin (HbA1c) and is associated with diabetic complications and metabolic diseases. However, information on the association between HGI and non‐alcoholic fatty liver disease (NAFLD) in healthy subj...

Full description

Saved in:
Bibliographic Details
Published in:Clinical endocrinology (Oxford) 2019-08, Vol.91 (2), p.271-277
Main Authors: Yoo, Jee Hee, Kang, Yu Mi, Cho, Yun Kyung, Lee, Jiwoo, Jung, Chang Hee, Park, Joong‐Yeol, Ryu, Ohk‐Hyun, Kim, Hong‐Kyu, Lee, Woo Je
Format: Article
Language:English
Subjects:
blood glucose
Body mass index
Body weight
Diabetes mellitus
Fatty liver
glucose
glycated haemoglobin A
Glycosylation
Hemoglobin
Liver diseases
Metabolic disorders
Metabolism
nonalcoholic fatty liver disease
Population studies
Regression analysis
Steatosis
Ultrasonic imaging
Ultrasound
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives The hemoglobin glycation index (HGI) quantifies interindividual variations in glycated hemoglobin (HbA1c) and is associated with diabetic complications and metabolic diseases. However, information on the association between HGI and non‐alcoholic fatty liver disease (NAFLD) in healthy subjects is limited, particularly in Asian populations. This study aimed to investigate the association between HGI and NAFLD in a healthy Korean cohort. Design Subjects were stratified in quartiles according to their HGI level. NAFLD was diagnosed by hepatic ultrasonography, hepatic steatosis index and fatty liver index. Multiple logistic regression analysis was performed to evaluate the association between HGI quartiles and the risk of NAFLD. Patients Data from subjects without diabetes who underwent liver ultrasonography during routine health examinations were retrospectively reviewed. Results Data from 14 465 subjects were included in the analysis. The prevalence of NAFLD increased significantly with each HGI quartile (24.8%, 29.7%, 32.6% and 40.6% in quartiles 1‐4, respectively; P 
ISSN:0300-0664
1365-2265
DOI:10.1111/cen.14001