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The haemoglobin glycation index is associated with nonalcoholic fatty liver disease in healthy subjects
Objectives The hemoglobin glycation index (HGI) quantifies interindividual variations in glycated hemoglobin (HbA1c) and is associated with diabetic complications and metabolic diseases. However, information on the association between HGI and non‐alcoholic fatty liver disease (NAFLD) in healthy subj...
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| Published in: | Clinical endocrinology (Oxford) 2019-08, Vol.91 (2), p.271-277 |
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| Main Authors: | , , , , , , , , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c3531-9072b495dc69fd71ca8b826db138ab9737163bc6344a9fff354cb0155e69d05d3 |
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| cites | cdi_FETCH-LOGICAL-c3531-9072b495dc69fd71ca8b826db138ab9737163bc6344a9fff354cb0155e69d05d3 |
| container_end_page | 277 |
| container_issue | 2 |
| container_start_page | 271 |
| container_title | Clinical endocrinology (Oxford) |
| container_volume | 91 |
| creator | Yoo, Jee Hee Kang, Yu Mi Cho, Yun Kyung Lee, Jiwoo Jung, Chang Hee Park, Joong‐Yeol Ryu, Ohk‐Hyun Kim, Hong‐Kyu Lee, Woo Je |
| description | Objectives
The hemoglobin glycation index (HGI) quantifies interindividual variations in glycated hemoglobin (HbA1c) and is associated with diabetic complications and metabolic diseases. However, information on the association between HGI and non‐alcoholic fatty liver disease (NAFLD) in healthy subjects is limited, particularly in Asian populations. This study aimed to investigate the association between HGI and NAFLD in a healthy Korean cohort.
Design
Subjects were stratified in quartiles according to their HGI level. NAFLD was diagnosed by hepatic ultrasonography, hepatic steatosis index and fatty liver index. Multiple logistic regression analysis was performed to evaluate the association between HGI quartiles and the risk of NAFLD.
Patients
Data from subjects without diabetes who underwent liver ultrasonography during routine health examinations were retrospectively reviewed.
Results
Data from 14 465 subjects were included in the analysis. The prevalence of NAFLD increased significantly with each HGI quartile (24.8%, 29.7%, 32.6% and 40.6% in quartiles 1‐4, respectively; P |
| doi_str_mv | 10.1111/cen.14001 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2218999002</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2258020272</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3531-9072b495dc69fd71ca8b826db138ab9737163bc6344a9fff354cb0155e69d05d3</originalsourceid><addsrcrecordid>eNp1kE1v1DAQQC0EokvhwB9AlrjAIe3Yjp34iFZtQargUs6RPyYbr7xxiZOW_Hu8bOGAhC9zefM0foS8ZXDByrt0OF6wGoA9IxsmlKw4V_I52YAAqECp-oy8ynkPALKF5iU5EwxqxUS7Ibu7Aelg8JB2Mdkw0l1cnZlDGmkYPf6kIVOTc3LBzOjpY5gHOqbRRJeGFIOjvZnnlcbwgBP1IaPJWDbpgCbOw0rzYvfo5vyavOhNzPjmaZ6T79dXd9vP1e23my_bT7eVE1KwSkPDba2ld0r3vmHOtLblyttyrLG6EQ1Twjol6trovu-FrJ0FJiUq7UF6cU4-nLz3U_qxYJ67Q8gOYzQjpiV3nLNWaw3AC_r-H3Sflql87UiVUBx4c6Q-nig3pZwn7Lv7KRzMtHYMumP9rtTvftcv7Lsn42IP6P-Sf3IX4PIEPIaI6_9N3fbq60n5C6B-jjA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2258020272</pqid></control><display><type>article</type><title>The haemoglobin glycation index is associated with nonalcoholic fatty liver disease in healthy subjects</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Yoo, Jee Hee ; Kang, Yu Mi ; Cho, Yun Kyung ; Lee, Jiwoo ; Jung, Chang Hee ; Park, Joong‐Yeol ; Ryu, Ohk‐Hyun ; Kim, Hong‐Kyu ; Lee, Woo Je</creator><creatorcontrib>Yoo, Jee Hee ; Kang, Yu Mi ; Cho, Yun Kyung ; Lee, Jiwoo ; Jung, Chang Hee ; Park, Joong‐Yeol ; Ryu, Ohk‐Hyun ; Kim, Hong‐Kyu ; Lee, Woo Je</creatorcontrib><description>Objectives
The hemoglobin glycation index (HGI) quantifies interindividual variations in glycated hemoglobin (HbA1c) and is associated with diabetic complications and metabolic diseases. However, information on the association between HGI and non‐alcoholic fatty liver disease (NAFLD) in healthy subjects is limited, particularly in Asian populations. This study aimed to investigate the association between HGI and NAFLD in a healthy Korean cohort.
Design
Subjects were stratified in quartiles according to their HGI level. NAFLD was diagnosed by hepatic ultrasonography, hepatic steatosis index and fatty liver index. Multiple logistic regression analysis was performed to evaluate the association between HGI quartiles and the risk of NAFLD.
Patients
Data from subjects without diabetes who underwent liver ultrasonography during routine health examinations were retrospectively reviewed.
Results
Data from 14 465 subjects were included in the analysis. The prevalence of NAFLD increased significantly with each HGI quartile (24.8%, 29.7%, 32.6% and 40.6% in quartiles 1‐4, respectively; P < 0.001). In comparison with the lowest HGI quartile group, the highest quartile exhibited worse metabolic parameters, including body weight, waist circumference, body mass index and lipid profiles. Multiple logistic regression analysis adjusted for multiple factors showed that the odds ratio of having NAFLD was 1.564 (95% CI: 1.350‐1.813, P < 0.001) in the highest HGI quartile.
Conclusions
Elevated HGI levels are independently associated with NAFLD in a healthy Asian population.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/cen.14001</identifier><identifier>PMID: 31046138</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>blood glucose ; Body mass index ; Body weight ; Diabetes mellitus ; Fatty liver ; glucose ; glycated haemoglobin A ; Glycosylation ; Hemoglobin ; Liver diseases ; Metabolic disorders ; Metabolism ; nonalcoholic fatty liver disease ; Population studies ; Regression analysis ; Steatosis ; Ultrasonic imaging ; Ultrasound</subject><ispartof>Clinical endocrinology (Oxford), 2019-08, Vol.91 (2), p.271-277</ispartof><rights>2019 John Wiley & Sons Ltd</rights><rights>2019 John Wiley & Sons Ltd.</rights><rights>Copyright © 2019 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3531-9072b495dc69fd71ca8b826db138ab9737163bc6344a9fff354cb0155e69d05d3</citedby><cites>FETCH-LOGICAL-c3531-9072b495dc69fd71ca8b826db138ab9737163bc6344a9fff354cb0155e69d05d3</cites><orcidid>0000-0002-2536-6274</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31046138$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoo, Jee Hee</creatorcontrib><creatorcontrib>Kang, Yu Mi</creatorcontrib><creatorcontrib>Cho, Yun Kyung</creatorcontrib><creatorcontrib>Lee, Jiwoo</creatorcontrib><creatorcontrib>Jung, Chang Hee</creatorcontrib><creatorcontrib>Park, Joong‐Yeol</creatorcontrib><creatorcontrib>Ryu, Ohk‐Hyun</creatorcontrib><creatorcontrib>Kim, Hong‐Kyu</creatorcontrib><creatorcontrib>Lee, Woo Je</creatorcontrib><title>The haemoglobin glycation index is associated with nonalcoholic fatty liver disease in healthy subjects</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol (Oxf)</addtitle><description>Objectives
The hemoglobin glycation index (HGI) quantifies interindividual variations in glycated hemoglobin (HbA1c) and is associated with diabetic complications and metabolic diseases. However, information on the association between HGI and non‐alcoholic fatty liver disease (NAFLD) in healthy subjects is limited, particularly in Asian populations. This study aimed to investigate the association between HGI and NAFLD in a healthy Korean cohort.
Design
Subjects were stratified in quartiles according to their HGI level. NAFLD was diagnosed by hepatic ultrasonography, hepatic steatosis index and fatty liver index. Multiple logistic regression analysis was performed to evaluate the association between HGI quartiles and the risk of NAFLD.
Patients
Data from subjects without diabetes who underwent liver ultrasonography during routine health examinations were retrospectively reviewed.
Results
Data from 14 465 subjects were included in the analysis. The prevalence of NAFLD increased significantly with each HGI quartile (24.8%, 29.7%, 32.6% and 40.6% in quartiles 1‐4, respectively; P < 0.001). In comparison with the lowest HGI quartile group, the highest quartile exhibited worse metabolic parameters, including body weight, waist circumference, body mass index and lipid profiles. Multiple logistic regression analysis adjusted for multiple factors showed that the odds ratio of having NAFLD was 1.564 (95% CI: 1.350‐1.813, P < 0.001) in the highest HGI quartile.
Conclusions
Elevated HGI levels are independently associated with NAFLD in a healthy Asian population.</description><subject>blood glucose</subject><subject>Body mass index</subject><subject>Body weight</subject><subject>Diabetes mellitus</subject><subject>Fatty liver</subject><subject>glucose</subject><subject>glycated haemoglobin A</subject><subject>Glycosylation</subject><subject>Hemoglobin</subject><subject>Liver diseases</subject><subject>Metabolic disorders</subject><subject>Metabolism</subject><subject>nonalcoholic fatty liver disease</subject><subject>Population studies</subject><subject>Regression analysis</subject><subject>Steatosis</subject><subject>Ultrasonic imaging</subject><subject>Ultrasound</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kE1v1DAQQC0EokvhwB9AlrjAIe3Yjp34iFZtQargUs6RPyYbr7xxiZOW_Hu8bOGAhC9zefM0foS8ZXDByrt0OF6wGoA9IxsmlKw4V_I52YAAqECp-oy8ynkPALKF5iU5EwxqxUS7Ibu7Aelg8JB2Mdkw0l1cnZlDGmkYPf6kIVOTc3LBzOjpY5gHOqbRRJeGFIOjvZnnlcbwgBP1IaPJWDbpgCbOw0rzYvfo5vyavOhNzPjmaZ6T79dXd9vP1e23my_bT7eVE1KwSkPDba2ld0r3vmHOtLblyttyrLG6EQ1Twjol6trovu-FrJ0FJiUq7UF6cU4-nLz3U_qxYJ67Q8gOYzQjpiV3nLNWaw3AC_r-H3Sflql87UiVUBx4c6Q-nig3pZwn7Lv7KRzMtHYMumP9rtTvftcv7Lsn42IP6P-Sf3IX4PIEPIaI6_9N3fbq60n5C6B-jjA</recordid><startdate>201908</startdate><enddate>201908</enddate><creator>Yoo, Jee Hee</creator><creator>Kang, Yu Mi</creator><creator>Cho, Yun Kyung</creator><creator>Lee, Jiwoo</creator><creator>Jung, Chang Hee</creator><creator>Park, Joong‐Yeol</creator><creator>Ryu, Ohk‐Hyun</creator><creator>Kim, Hong‐Kyu</creator><creator>Lee, Woo Je</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2536-6274</orcidid></search><sort><creationdate>201908</creationdate><title>The haemoglobin glycation index is associated with nonalcoholic fatty liver disease in healthy subjects</title><author>Yoo, Jee Hee ; Kang, Yu Mi ; Cho, Yun Kyung ; Lee, Jiwoo ; Jung, Chang Hee ; Park, Joong‐Yeol ; Ryu, Ohk‐Hyun ; Kim, Hong‐Kyu ; Lee, Woo Je</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3531-9072b495dc69fd71ca8b826db138ab9737163bc6344a9fff354cb0155e69d05d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>blood glucose</topic><topic>Body mass index</topic><topic>Body weight</topic><topic>Diabetes mellitus</topic><topic>Fatty liver</topic><topic>glucose</topic><topic>glycated haemoglobin A</topic><topic>Glycosylation</topic><topic>Hemoglobin</topic><topic>Liver diseases</topic><topic>Metabolic disorders</topic><topic>Metabolism</topic><topic>nonalcoholic fatty liver disease</topic><topic>Population studies</topic><topic>Regression analysis</topic><topic>Steatosis</topic><topic>Ultrasonic imaging</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoo, Jee Hee</creatorcontrib><creatorcontrib>Kang, Yu Mi</creatorcontrib><creatorcontrib>Cho, Yun Kyung</creatorcontrib><creatorcontrib>Lee, Jiwoo</creatorcontrib><creatorcontrib>Jung, Chang Hee</creatorcontrib><creatorcontrib>Park, Joong‐Yeol</creatorcontrib><creatorcontrib>Ryu, Ohk‐Hyun</creatorcontrib><creatorcontrib>Kim, Hong‐Kyu</creatorcontrib><creatorcontrib>Lee, Woo Je</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoo, Jee Hee</au><au>Kang, Yu Mi</au><au>Cho, Yun Kyung</au><au>Lee, Jiwoo</au><au>Jung, Chang Hee</au><au>Park, Joong‐Yeol</au><au>Ryu, Ohk‐Hyun</au><au>Kim, Hong‐Kyu</au><au>Lee, Woo Je</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The haemoglobin glycation index is associated with nonalcoholic fatty liver disease in healthy subjects</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol (Oxf)</addtitle><date>2019-08</date><risdate>2019</risdate><volume>91</volume><issue>2</issue><spage>271</spage><epage>277</epage><pages>271-277</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><abstract>Objectives
The hemoglobin glycation index (HGI) quantifies interindividual variations in glycated hemoglobin (HbA1c) and is associated with diabetic complications and metabolic diseases. However, information on the association between HGI and non‐alcoholic fatty liver disease (NAFLD) in healthy subjects is limited, particularly in Asian populations. This study aimed to investigate the association between HGI and NAFLD in a healthy Korean cohort.
Design
Subjects were stratified in quartiles according to their HGI level. NAFLD was diagnosed by hepatic ultrasonography, hepatic steatosis index and fatty liver index. Multiple logistic regression analysis was performed to evaluate the association between HGI quartiles and the risk of NAFLD.
Patients
Data from subjects without diabetes who underwent liver ultrasonography during routine health examinations were retrospectively reviewed.
Results
Data from 14 465 subjects were included in the analysis. The prevalence of NAFLD increased significantly with each HGI quartile (24.8%, 29.7%, 32.6% and 40.6% in quartiles 1‐4, respectively; P < 0.001). In comparison with the lowest HGI quartile group, the highest quartile exhibited worse metabolic parameters, including body weight, waist circumference, body mass index and lipid profiles. Multiple logistic regression analysis adjusted for multiple factors showed that the odds ratio of having NAFLD was 1.564 (95% CI: 1.350‐1.813, P < 0.001) in the highest HGI quartile.
Conclusions
Elevated HGI levels are independently associated with NAFLD in a healthy Asian population.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31046138</pmid><doi>10.1111/cen.14001</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-2536-6274</orcidid></addata></record> |
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| ispartof | Clinical endocrinology (Oxford), 2019-08, Vol.91 (2), p.271-277 |
| issn | 0300-0664 1365-2265 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2218999002 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | blood glucose Body mass index Body weight Diabetes mellitus Fatty liver glucose glycated haemoglobin A Glycosylation Hemoglobin Liver diseases Metabolic disorders Metabolism nonalcoholic fatty liver disease Population studies Regression analysis Steatosis Ultrasonic imaging Ultrasound |
| title | The haemoglobin glycation index is associated with nonalcoholic fatty liver disease in healthy subjects |
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