Combined cereal and pulse flavonoids show enhanced bioavailability by downregulating phase II metabolism and ABC membrane transporter function in Caco-2 model

•Cereals and pulses are complementary dietary commodities.•Cereals and pulse flavonoids are structurally different.•Combined cereal flavones and pulse flavonols show enhanced absorption.•Effect due to suppression of phase II metabolism and ABC transporter function.•Strategic combinations of cereal a...

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Bibliographic Details
Published in:Food chemistry 2019-05, Vol.279, p.88-97
Main Authors: Ravisankar, Shreeya, Agah, Shima, Kim, Hyemee, Talcott, Susanne, Wu, Chaodong, Awika, Joseph
Format: Article
Language:English
Subjects:
ABC transporter
adenosine triphosphate
adenosinetriphosphatase
apigenin
Apigenin - metabolism
Apigenin - pharmacology
ATP-Binding Cassette Transporters - genetics
ATP-Binding Cassette Transporters - metabolism
bioactive properties
bioavailability
Biological Availability
Caco-2 Cells
Cell Membrane Permeability - drug effects
Cereal grain
diet
Down-Regulation - drug effects
Edible Grain - metabolism
enzyme inhibition
Flavanones - metabolism
Flavanones - pharmacology
Flavonoid
Flavonoids - metabolism
Flavonoids - pharmacology
Grain pulses
grains
Humans
membrane permeability
metabolism
naringenin
P-glycoproteins
Phase II metabolism
Polyphenol bioavailability
quercetin
Quercetin - metabolism
Quercetin - pharmacology
Synergistic interaction
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Summary:•Cereals and pulses are complementary dietary commodities.•Cereals and pulse flavonoids are structurally different.•Combined cereal flavones and pulse flavonols show enhanced absorption.•Effect due to suppression of phase II metabolism and ABC transporter function.•Strategic combinations of cereal and pulses could enhance biological benefits. Predominant flavonoids in cereals and pulses are structurally different and may positively interact to enhance bioactivity in combined diet. This work investigated the effects of combined cereal 3-deoxyflavonoids (apigenin, naringenin) and pulse flavonols (quercetin), along with natural extracts, on their bioavailability and underlying mechanisms using Caco-2 monolayer model. Membrane permeability, phase II metabolism, and ATP binding cassette (ABC) membrane transporter expression and function were measured. Apparent absorption of quercetin and apigenin increased (p 
ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2018.12.006