Inflammasome Inhibition Links IRGM to Innate Immunity

IRGM is a risk factor for several inflammatory diseases, yet no direct link to immune regulation had been shown. In this issue of Molecular Cell, Mehto et al. (2019) report that IRGM limits NLRP3 inflammasome activation—by both direct inhibition of NLRP3/ASC oligomerization and selective autophagic...

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Bibliographic Details
Published in:Molecular cell 2019-02, Vol.73 (3), p.391-392
Main Authors: Nabar, Neel R., Kehrl, John H.
Format: Article
Language:English
Subjects:
Autophagy
Crohn Disease
GTP-Binding Proteins
Humans
Immunity, Innate
Inflammasomes
NLR Family, Pyrin Domain-Containing 3 Protein
Risk Factors
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Summary:IRGM is a risk factor for several inflammatory diseases, yet no direct link to immune regulation had been shown. In this issue of Molecular Cell, Mehto et al. (2019) report that IRGM limits NLRP3 inflammasome activation—by both direct inhibition of NLRP3/ASC oligomerization and selective autophagic destruction of NLRP3/ASC. IRGM is a risk factor for several inflammatory diseases, yet no direct link to immune regulation had been shown. In this issue of Molecular Cell, Mehto et al. (2019) report that IRGM limits NLRP3 inflammasome activation—by both direct inhibition of NLRP3/ASC oligomerization and selective autophagic destruction of NLRP3/ASC.
ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2019.01.029