Durability of first-line antiretroviral regimens in the era of integrase inhibitors: a cohort of HIV-positive individuals in Spain, 2014-2015

We compared time to treatment change (TC), viral suppression (VS) and change in CD4 T-cell counts of first-line antiretroviral regimens (ART). We analysed HIV treatment-naive adults from the Cohort of the Spanish HIV/AIDS Research Network (CoRIS) initiating the most commonly used ART regimens from S...

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Bibliographic Details
Published in:Antiviral therapy 2019-01, Vol.24 (3), p.167-175
Main Authors: Jarrin, Inmaculada, Suarez-Garcia, Ines, Moreno, Cristina, Tasias, Maria, Del Romero, Jorge, Palacios, Rosario, Peraire, Joaquim, Gorgolas, Miguel, Moreno, Santiago
Format: Article
Language:English
Subjects:
Abacavir
Acquired immune deficiency syndrome
Adult
Aged
AIDS
Anti-HIV Agents - administration & dosage
Anti-HIV Agents - adverse effects
Anti-HIV Agents - therapeutic use
Antiretroviral drugs
Antiretroviral therapy
Antiretroviral Therapy, Highly Active
CD4 antigen
CD4 Lymphocyte Count
Decision making
Drug Substitution
Efavirenz
Emtricitabine
Female
History, 21st Century
HIV
HIV Infections - diagnosis
HIV Infections - drug therapy
HIV Infections - epidemiology
HIV Infections - history
HIV Seropositivity - drug therapy
HIV Seropositivity - epidemiology
HIV Seropositivity - history
Human immunodeficiency virus
Humans
Integrase
Integrase Inhibitors - administration & dosage
Integrase Inhibitors - adverse effects
Integrase Inhibitors - therapeutic use
Lamivudine
Lymphocytes T
Male
Middle Aged
Public Health Surveillance
Ritonavir
Socioeconomic Factors
Spain - epidemiology
Tenofovir
Treatment Outcome
Viral Load
Young Adult
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Summary:We compared time to treatment change (TC), viral suppression (VS) and change in CD4 T-cell counts of first-line antiretroviral regimens (ART). We analysed HIV treatment-naive adults from the Cohort of the Spanish HIV/AIDS Research Network (CoRIS) initiating the most commonly used ART regimens from September 2014 to November 2015. We used proportional hazards models on the sub-distribution hazard to estimate sub-distribution hazard ratios (sHR) for time to TC, logistic regression to estimate odds ratios (ORs) for VS (viral load
ISSN:1359-6535
2040-2058
DOI:10.3851/IMP3297