Thiol-Disulfide Homeostasis, Serum Ferroxidase Activity, and Serum Ischemia Modified Albumin Levels in Neonatal Jaundice

Aim: Hyperbilirubinemia causes oxidative stress. Method: We evaluated three oxidative stress markers in hyperbilirubinemic neonates (native/total thiol levels, serum ferroxidase activity and ischemia modified albumin (IMA), comparing these levels to levels in a control group to determine which indic...

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Bibliographic Details
Published in:Fetal and pediatric pathology 2019-04, Vol.38 (2), p.138-145
Main Authors: Topal, Ismail, Mertoglu, Cuma, Surucu Kara, Ilknur, Siranli, Gulsah, Gok, Gamze, Erel, Özcan
Format: Article
Language:English
Subjects:
Biomarkers - blood
Ceruloplasmin - biosynthesis
Disulfides - blood
ferroxidase
Homeostasis - physiology
Humans
Infant
Infant, Newborn
ischemia modified albumin
Jaundice, Neonatal - blood
neonatal jaundice
Oxidative Stress - physiology
Serum Albumin - biosynthesis
Serum Albumin, Human
Sulfhydryl Compounds - blood
thiol/disulfide homeostasis
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Summary:Aim: Hyperbilirubinemia causes oxidative stress. Method: We evaluated three oxidative stress markers in hyperbilirubinemic neonates (native/total thiol levels, serum ferroxidase activity and ischemia modified albumin (IMA), comparing these levels to levels in a control group to determine which indicators were the most sensitive. Results: Serum from 124 term infants (67 with pathologic jaundice and 57 controls) were evaluated. Native/total thiol ratio was significantly lower (p:0.021) while disulfide levels were significantly higher (p:0.001) in the jaundiced group. There was no significant difference in ferroxidase (p:0.603) or IMA (p:0.251) levels. Conclusion: Altered thiol/disulfide homeostasis in the favor of disulfide indicates augmented oxidative stress in jaundiced term infants. The lack of alteration in ferroxidase or IMA levels suggests these latter alterations take more time or more severe oxidative stress to become altered or are not as sensitive as the thiol/disulfide ratio to detect oxidative stress states.
ISSN:1551-3815
1551-3823
DOI:10.1080/15513815.2018.1561772