Duodenojejunal Bypass Plus Sleeve Gastrectomy Reduces Infiltration of Macrophages and Secretion of TNF-α in the Visceral White Adipose Tissue of Goto-Kakizaki Rats

Background Current studies indicate that inflammation of white adipose tissue (WAT) is a pathogenic characteristic of insulin resistance. However, the significance of visceral WAT inflammation after bariatric surgery remains unclear. Methods Duodenojejunal bypass plus sleeve gastrectomy (DJB-SG) was...

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Bibliographic Details
Published in:Obesity surgery 2019-06, Vol.29 (6), p.1742-1750
Main Authors: Yu, Hao, Song, Zhigao, Zhang, Hongbin, Zheng, Kehong, Zhan, Junfang, Luo, Qing, Sun, Jingbo, Liang, Li, Dai, Xiaojiang, Wu, Liangping
Format: Article
Language:English
Subjects:
Animals
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - surgery
Disease Models, Animal
Duodenum - surgery
Gastrectomy
Gastric Bypass
Gastrointestinal surgery
Glucose
Glucose Tolerance Test
Inflammation
Insulin Resistance
Intra-Abdominal Fat - metabolism
Jejunum - surgery
Macrophages - physiology
Male
Medicine
Medicine & Public Health
Original Contributions
Rats
Surgery
Tumor Necrosis Factor-alpha - metabolism
Tumor necrosis factor-TNF
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Summary:Background Current studies indicate that inflammation of white adipose tissue (WAT) is a pathogenic characteristic of insulin resistance. However, the significance of visceral WAT inflammation after bariatric surgery remains unclear. Methods Duodenojejunal bypass plus sleeve gastrectomy (DJB-SG) was performed on Goto-Kakisaki rats. Weight, fasting blood glucose (FBG), and homeostatic model assessment of insulin resistance (HOMA-IR) in the DJB-SG group were compared to those in a sham surgery (SHAM) group every 2 weeks. The results of an oral glucose tolerance test (OGTT) and the volume of visceral adipose tissue (Visc.Fat) were compared before and 8 weeks postsurgery. Eight weeks after surgery, the rats were sacrificed and visceral WAT collected from the greater omentum. Tumor necrosis factor-α (TNF-α) and cluster of differentiation 68 (CD68) expression in the WAT were evaluated in paraffin-embedded sections by immunohistochemistry. Results Compared with the SHAM group, the DJB-SG group demonstrated a significant reduction in weight, FBG, and HOMA-IR ( P  
ISSN:0960-8923
1708-0428
DOI:10.1007/s11695-019-03755-1