Sex-specific association between soluble corin and metabolic syndrome in Chinese adults

Soluble corin has been associated with cardiovascular disease and its risk factors, but whether it is associated with metabolic syndrome (MetS), a cluster of cardiometabolic disorders, remains unclear. We aimed to examine the association between soluble corin and MetS in Chinese men and women. We ex...

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Bibliographic Details
Published in:Hypertension research 2019-07, Vol.42 (7), p.1029-1035
Main Authors: Li, Hongmei, Zhang, Qiu, He, Yan, Shi, Jijun, Hu, Weidong, Peng, Hao
Format: Article
Language:English
Subjects:
Adult
Aged
Asian Continental Ancestry Group
Cardiovascular disease
China
Cross-Sectional Studies
Enzymes
Female
Gender differences
Health risk assessment
Health risks
Humans
Male
Mens health
Metabolic syndrome
Metabolic Syndrome - blood
Middle Aged
Risk Factors
Serine Endopeptidases - blood
Sex Factors
Women
Womens health
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Summary:Soluble corin has been associated with cardiovascular disease and its risk factors, but whether it is associated with metabolic syndrome (MetS), a cluster of cardiometabolic disorders, remains unclear. We aimed to examine the association between soluble corin and MetS in Chinese men and women. We examined serum soluble corin using immunoassays in 962 men (mean age, 53 years) and 1536 women (mean age, 54 years) free of cardiovascular disease. Logistic regression was applied to examine the association between soluble corin and MetS in men and women. The results showed that participants in the 3rd and 4th quartiles of serum soluble corin had 1.99 (95% CI: 1.32-3.00) and 3.84 (95% CI: 2.54-5.83) times the risk of having MetS for men and 1.48 (95% CI: 1.06-2.06) and 1.53 (95% CI: 1.10-2.12) times the risk of having MetS for women compared to those in the lowest quartile. The magnitude of the association between serum soluble corin and MetS was significantly stronger for men than for women (P 
ISSN:0916-9636
1348-4214
DOI:10.1038/s41440-019-0228-4