Berberine as a potential autophagy modulator

Today, pharmacognosy is considered a valuable science in the prevention and treatment of diseases. Among herbals, Berberine is an isoquinoline alkaloid found in the Berberis species. Surprisingly, it shows antimicrobial, antiviral, antidiarrheal, antipyretic, and anti‐inflammatory potential. Further...

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Bibliographic Details
Published in:Journal of cellular physiology 2019-09, Vol.234 (9), p.14914-14926
Main Authors: Mohammadinejad, Reza, Ahmadi, Zahra, Tavakol, Shima, Ashrafizadeh, Milad
Format: Article
Language:English
Subjects:
Autophagy
Berberine
Cancer
Cancer therapies
Cell cycle
Cell death
Drug resistance
drug‐resistant
Inflammation
Medical treatment
Phagocytosis
Pharmacognosy
Pharmacology
programmed cell death
Therapy
Tumor suppression
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Summary:Today, pharmacognosy is considered a valuable science in the prevention and treatment of diseases. Among herbals, Berberine is an isoquinoline alkaloid found in the Berberis species. Surprisingly, it shows antimicrobial, antiviral, antidiarrheal, antipyretic, and anti‐inflammatory potential. Furthermore, it diminishes drug resistance in cancer therapy and enhances tumor suppression in part through autophagy and cell cycle arrest mechanisms. In the present review, we discuss the effect of berberine on diverse cellular pathways and describe how berberine acts as an autophagy modulator to adjust physiologic and pathologic conditions and diminishes drug resistance in cancer therapy. Among herbals, Berberine is an isoquinoline alkaloid found in the Berberis species. Furthermore, it diminishes drug resistance in cancer therapy and enhances tumor suppression in part through autophagy and cell cycle arrest mechanisms.
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.28325