Central aspects of systemic oestradiol negative‐ and positive‐feedback on the reproductive neuroendocrine system

The central nervous system regulates fertility via the release of gonadotrophin‐releasing hormone (GnRH). This control revolves around the hypothalamic‐pituitary‐gonadal axis, which operates under traditional homeostatic feedback by sex steroids from the gonads in males and most of the time in femal...

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Bibliographic Details
Published in:Journal of neuroendocrinology 2020-01, Vol.32 (1), p.e12724-n/a
Main Authors: Moenter, Suzanne M., Silveira, Marina A., Wang, Luhong, Adams, Caroline
Format: Article
Language:English
Subjects:
Central nervous system
Feedback
GnRH
Gonadotropin-releasing hormone
Gonads
Hypothalamus
Neuroendocrine system
oestradiol
Ovulation
Pituitary
Pituitary (anterior)
Sex hormones
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Summary:The central nervous system regulates fertility via the release of gonadotrophin‐releasing hormone (GnRH). This control revolves around the hypothalamic‐pituitary‐gonadal axis, which operates under traditional homeostatic feedback by sex steroids from the gonads in males and most of the time in females. An exception is the late follicular phase in females, when homeostatic feedback is suspended and a positive‐feedback response to oestradiol initiates the preovulatory surges of GnRH and luteinising hormone. Here, we briefly review the history of how mechanisms underlying central control of ovulation by circulating steroids have been studied, discuss the relative merit of different model systems and integrate some of the more recent findings in this area into an overall picture of how this phenomenon occurs.
ISSN:0953-8194
1365-2826
DOI:10.1111/jne.12724