Prognostic Value and Prediction of Extratumoral Microvascular Invasion for Hepatocellular Carcinoma

Background There are few reports on microvascular invasion (MVI) located intra- or extratumorally and prognosis of hepatocellular carcinoma (HCC). Objective The aim of this study was to evaluate patient outcome according to the location of MVI, and to build a nomogram predicting extratumoral MVI. Me...

Full description

Saved in:
Bibliographic Details
Published in:Annals of surgical oncology 2019-08, Vol.26 (8), p.2568-2576
Main Authors: Nitta, Hidetoshi, Allard, Marc-Antoine, Sebagh, Mylène, Ciacio, Oriana, Pittau, Gabriella, Vibert, Eric, Sa Cunha, Antonio, Cherqui, Daniel, Castaing, Denis, Bismuth, Henri, Guettier, Catherine, Lewin, Maité, Samuel, Didier, Baba, Hideo, Adam, René
Format: Article
Language:English
Subjects:
Alkaline phosphatase
alpha-Fetoproteins - metabolism
Aspartate aminotransferase
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - surgery
Cohort Studies
Female
Follow-Up Studies
Hepatectomy - mortality
Hepatobiliary Tumors
Hepatocellular carcinoma
Humans
Invasiveness
Liver cancer
Liver Neoplasms - metabolism
Liver Neoplasms - pathology
Liver Neoplasms - surgery
Liver transplantation
Liver Transplantation - mortality
Male
Medical prognosis
Medicine
Medicine & Public Health
Microvasculature
Microvessels - metabolism
Microvessels - pathology
Microvessels - surgery
Middle Aged
Multivariate analysis
Neoplasm Invasiveness
Neoplasm Recurrence, Local - metabolism
Neoplasm Recurrence, Local - pathology
Neoplasm Recurrence, Local - surgery
Nomograms
Oncology
Patients
Prognosis
Risk factors
Surgery
Surgical Oncology
Survival Rate
Vascular Neoplasms - metabolism
Vascular Neoplasms - pathology
Vascular Neoplasms - surgery
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background There are few reports on microvascular invasion (MVI) located intra- or extratumorally and prognosis of hepatocellular carcinoma (HCC). Objective The aim of this study was to evaluate patient outcome according to the location of MVI, and to build a nomogram predicting extratumoral MVI. Methods We included 681 consecutive patients who underwent hepatic resection (HR) or liver transplantation (LT) for HCC from January 1994 to June 2012, and evaluated patient outcome according to the degree of vascular invasion (VI). A nomogram for predicting extratumoral MVI was created using 637 patients, excluding 44 patients with macrovascular invasion, and was validated using an internal ( n  = 273) and external patient cohort ( n  = 256). Results The 681 patients were classified into four groups based on pathological examination (148 no VI, 33 intratumoral MVI, 84 extratumoral MVI, and 29 macrovascular invasion in patients who underwent HR; 238 no VI, 50 intratumoral MVI, 84 extratumoral MVI, and 15 macrovascular invasion in patients who underwent LT). Multivariate analysis revealed that extratumoral MVI was an independent risk factor for overall survival in patients who underwent HR (hazard ratio 2.62, p  
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-019-07365-0