Osteogenic activity and antibacterial ability on titanium surfaces modified with magnesium-doped titanium dioxide coating

To improve the bioactivity and antibacterial activity of titanium (Ti) implants. Magnesium (Mg)-doped titanium dioxide microporous coatings (Mg-TiO ) were prepared on the surface of Ti implants by plasma electrolytic oxidation. Ti surfaces were covered with porous Mg-TiO , and Mg was evenly distribu...

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Bibliographic Details
Published in:Nanomedicine (London, England) England), 2019-05, Vol.14 (9), p.1109-1133
Main Authors: Zhao, Quanming, Yi, Lei, Jiang, Libo, Ma, Yiqun, Lin, Hong, Dong, Jian
Format: Article
Language:English
Subjects:
antibacterial activity
Bacteria
Biocompatibility
Biological activity
Biomedical materials
Bond strength
Bone marrow
Corrosion resistance
Hydroxyapatite
Kinases
Magnesium
magnesium coating
Mechanical properties
Metal fatigue
Mineralization
molecular mechanism
osseointegration
osteogenesis
plasma electrolytic oxidation
Prostheses
titanium
Titanium alloys
Transplants & implants
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Summary:To improve the bioactivity and antibacterial activity of titanium (Ti) implants. Magnesium (Mg)-doped titanium dioxide microporous coatings (Mg-TiO ) were prepared on the surface of Ti implants by plasma electrolytic oxidation. Ti surfaces were covered with porous Mg-TiO , and Mg was evenly distributed throughout the coating. Mg-TiO could not only promote osteoblast adhesion, proliferation and differentiation but also inhibit the colonization and growth of . In addition, Mg-TiO may promote osteogenesis through the ERK/c-Fos signaling pathway as well as the early osseointegration of Ti implants. Mg-TiO has both osteogenic and antibacterial effects and thus presents important theoretical significance and clinical potential.
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2018-0413