Neuroinflammation is a putative target for the prevention and treatment of perioperative neurocognitive disorders

The demographics of aging of the surgical population has increased the risk for perioperative neurocognitive disorders in which trauma-induced neuroinflammation plays a pivotal role. After determining the scope of the review, the authors used PubMed with select phrases encompassing the words in the...

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Bibliographic Details
Published in:British medical bulletin 2019-06, Vol.130 (1), p.125-135
Main Authors: Saxena, S, Lai, I K, Li, R, Maze, M
Format: Article
Language:English
Subjects:
Aging - immunology
Humans
Inflammation - drug therapy
Inflammation - immunology
Inflammation - physiopathology
Inflammation - prevention & control
Neurocognitive Disorders - drug therapy
Neurocognitive Disorders - immunology
Neurocognitive Disorders - physiopathology
Neurocognitive Disorders - prevention & control
Perioperative Care
Risk Factors
Wound Healing - immunology
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Summary:The demographics of aging of the surgical population has increased the risk for perioperative neurocognitive disorders in which trauma-induced neuroinflammation plays a pivotal role. After determining the scope of the review, the authors used PubMed with select phrases encompassing the words in the scope. Both preclinical and clinical reports were considered. Neuroinflammation is a sine qua non for development of perioperative neurocognitive disorders. What is the best method for ameliorating trauma-induced neuroinflammation while preserving inflammation-based wound healing. This review considers how to prepare for and manage the vulnerable elderly surgical patient through the entire spectrum, from preoperative assessment to postoperative period. What are the most effective and safest interventions for preventing and/or reversing Perioperative Neurocognitive Disorders.
ISSN:0007-1420
1471-8391
DOI:10.1093/bmb/ldz010