CD markers variations in chronic lymphocytic leukemia: New insights into prognosis

• Published in: Journal of cellular physiology 2019-11, Vol.234 (11), p.19420-19439
• Main Authors: Vosoughi, Tina, Bagheri, Marziye, Hosseinzadeh, Mehran, Ehsanpour, Ali, Davari, Nader, Saki, Najmaldin
• Format: Article
• Language: English
• Subjects: Abnormalities; Agent Orange; Antigens, CD - genetics; Apoptosis; Apoptosis - genetics; B-Lymphocytes - metabolism; B-Lymphocytes - pathology; Biomarkers; Biomarkers, Tumor - genetics; Bone marrow; CD markers; Change detection; Chronic lymphocytic leukemia; Clonal Evolution - genetics; Cytogenetics; Gene Expression Regulation, Leukemic - genetics; Humans; Immunodeficiency; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell - genetics; Leukemia, Lymphocytic, Chronic, B-Cell - metabolism; Leukemia, Lymphocytic, Chronic, B-Cell - pathology; Lymphatic leukemia; Lymphocytes; Lymphocytes - metabolism; Lymphocytes B; Pathogenesis; Peripheral blood; Prognosis; Tumor Microenvironment - genetics
• ISSN: 0021-9541; 1097-4652
• DOI: 10.1002/jcp.28724

Chronic lymphocytic leukemia (CLL) is one of the most commonly occurring adult leukemias that is associated with clonal accumulation of mature apoptosis‐resistant B‐cells in bone marrow, peripheral blood, and specific tissues. Different pathogenesis factors can contribute to the aggression of the clinical course in this disease. Cytogenetic abnormalities and surface biomarkers of neoplastic CLL cells can be effective in the outcome of CLL, and the examination of changing CD markers expressions in the progression of CLL can be related to the prognosis of this disease. Changing expression levels of CD markers on lymphocytes and other cells in CLL patients can play a role in the aggressive clinical outcomes such as organomegaly, immunodeficiency, and advanced disease stages through their interaction with CLL microenvironment. Given the involvement of CD markers in the pathogenesis of CLL, it can be stated that recognizing the expression changes of CD markers in the cells involved in CLL can be a proper approach to evaluate prognosis among these patients. Chronic lymphocytic leukemia (CLL) is one of the most commonly occurring adult leukemias that various pathogenesis factors can contribute to the aggression of the clinical course in this disease. The examination of changing CD markers expressions as one of these factors can be related to the prognosis of CLL.