Fractional flow reserve guided percutaneous coronary intervention optimization directed by high-definition intravascular ultrasound versus standard of care: Rationale and study design of the prospective randomized FFR-REACT trial

Post percutaneous coronary intervention (PCI) fractional flow reserve (FFR) is a significant predictor of major adverse cardiac events (MACE). The rationale for low post procedural FFR values often remains elusive based on angiographic findings alone, warranting further assessment using an FFR pullb...

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Bibliographic Details
Published in:The American heart journal 2019-07, Vol.213, p.66-72
Main Authors: van Zandvoort, Laurens J.C., Masdjedi, Kaneshka, Tovar Forero, Maria Natalia, Lenzen, Mattie J., Ligthart, Jurgen, Diletti, Roberto, Lemmert, Miguel E., Wilschut, Jeroen, de Jaegere, Peter P.T., Zijlstra, Felix, van Mieghem, Nicolas M., Daemen, Joost
Format: Article
Language:English
Subjects:
Angina
Angina, Stable - physiopathology
Angina, Stable - therapy
Angioplasty
Blood vessels
Cardiovascular disease
Coronary vessels
Dissection
Endosonography - methods
Fractional Flow Reserve, Myocardial
Heart
Heart attacks
Humans
Implants
Intervention
Kidneys
Medical imaging
Mortality
Myocardial infarction
Myocardial Revascularization
Non-ST Elevated Myocardial Infarction - physiopathology
Non-ST Elevated Myocardial Infarction - therapy
Optimization
Patients
Percutaneous Coronary Intervention - methods
Prospective Studies
Randomization
Randomized Controlled Trials as Topic
Standard of Care
Stents
Surgical implants
Thromboembolism
Thrombosis
Ultrasonic imaging
Ultrasound
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Description
Summary:Post percutaneous coronary intervention (PCI) fractional flow reserve (FFR) is a significant predictor of major adverse cardiac events (MACE). The rationale for low post procedural FFR values often remains elusive based on angiographic findings alone, warranting further assessment using an FFR pullback or additional intravascular imaging. It is currently unknown if additional interventions intended to improve the PCI, decrease MACE rates. The FFR REACT trial is a prospective, single-center randomized controlled trial in which 290 patients with a post PCI FFR
ISSN:0002-8703
1097-6744
DOI:10.1016/j.ahj.2019.03.017