Collateral circulation and Toll-like receptor 4 levels in patients with acute cerebral infarction after intravenous thrombolysis

To investigate the relationship between Toll-like receptor 4 (TLR4) and collateral circulation in patients with acute cerebral infarction (AIS) after thrombolytic therapy. This retrospective, observational cohort study was conducted among 65 patients with AIS receiving thrombolytic therapy, who were...

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Published in:Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2019-05, Vol.39 (5), p.621-626
Main Authors: Ji, Zhengxiang, Fang, Qi, Yu, Liqiang
Format: Article
Language:Chinese
Subjects:
Biomarkers
Brain Ischemia
Cerebral Infarction
Cerebrovascular Circulation
Cohort Studies
Collateral Circulation
Fibrinolytic Agents
Humans
Retrospective Studies
Stroke - metabolism
Stroke - therapy
Thrombolytic Therapy
Toll-Like Receptor 4 - metabolism
Treatment Outcome
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Summary:To investigate the relationship between Toll-like receptor 4 (TLR4) and collateral circulation in patients with acute cerebral infarction (AIS) after thrombolytic therapy. This retrospective, observational cohort study was conducted among 65 patients with AIS receiving thrombolytic therapy, who were divided according to findings by computed tomographic angiography (CTA) into good collateral circulation (group A, = 34) and poor collateral circulation (group B, = 31). Serum samples were collected from all the patients and the levels of TLR4 were measured with ELISA. The patients in group A had significantly better outcomes than those in group B. The NIHSS scores at 24 h and 30 days after thrombolytic therapy, mRS scores at 90 days and serum TLR4 levels were significantly lower in group A than in group B ( < 0.05); the percentages of patients with symptomatic intracerebral hemorrhage were comparable between the two groups. The serum levels of TLR4 were negatively correlated with the rMLC score ( < 0.05). Multiva
ISSN:1673-4254
DOI:10.12122/j.issn.1673-4254.2019.05.20