Derivatization approaches and applications of pullulan

Pullulan (PUL), a linear exo-polysaccharide, is useful in industries as diverse as food, cosmetics and pharmaceuticals. PUL presents many favorable characteristics, such as renewable origin, biocompatibility, stability, hydrophilic nature, and availability of reactive sites for chemical modification...

Full description

Saved in:
Bibliographic Details
Published in:Advances in colloid and interface science 2019-07, Vol.269, p.296-308
Main Authors: Tiwari, Sanjay, Patil, Rahul, Dubey, Sunil K., Bahadur, Pratap
Format: Article
Language:English
Subjects:
Chemical modification
Drug delivery
Polysaccharide
Pullulan
Self assembly
Tissue engineering
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Pullulan (PUL), a linear exo-polysaccharide, is useful in industries as diverse as food, cosmetics and pharmaceuticals. PUL presents many favorable characteristics, such as renewable origin, biocompatibility, stability, hydrophilic nature, and availability of reactive sites for chemical modification. With an inherent affinity to asialoglycoprotein receptors, PUL can be used for targeted drug delivery to the liver. Besides, these primary properties have been combined with modern synthetic approaches for developing multifunctional biomaterials. This is evident from numerous studies on approaches, such as hydrophobic modification, cross-linking, grafting and transformation as a polyelectrolyte. In this review, we have discussed up-to-date advances on chemical modifications and emerging applications of PUL in targeted theranostics and tissue engineering. Besides, we offer an overview of its applications in food, cosmetics and environment remediation. [Display omitted] •Pullulan (PUL), an uncharged, linear exopolysaccharide has ‘generally regarded as safe’ (GRAS) status.•Produced from agricultural wastes, PUL shows unique solution behavior and biological activity.•Chemically modified PUL and its polyblends are of potential use in drug delivery and tissue engineering.•Introduction of charged or thermo- and pH responsive groups enable its usage for specialized applications.
ISSN:0001-8686
1873-3727
DOI:10.1016/j.cis.2019.04.014