Aqueous humor IL-8, IL-10, and VEGF levels in Fuchs’ uveitis syndrome and Behçet’s uveitis

• Published in: International ophthalmology 2019-11, Vol.39 (11), p.2629-2636
• Main Authors: Simsek, Mert, Cakar Ozdal, Pinar, Akbiyik, Filiz, Citirik, Mehmet, Berker, Nilufer, Ozdamar Erol, Yasemin, Yilmazbas, Pelin
• Format: Article
• Language: English
• Subjects: Adult; Aqueous Humor - metabolism; Behcet Syndrome - diagnosis; Behcet Syndrome - metabolism; Biomarkers - metabolism; Case-Control Studies; Control methods; Enzyme-Linked Immunosorbent Assay; Female; Growth factors; Humans; Interleukin 10; Interleukin 8; Interleukin-10 - metabolism; Interleukin-8 - metabolism; Interleukins; Male; Medicine; Medicine & Public Health; Middle Aged; Ophthalmology; Original Paper; Physical growth; Prospective Studies; Syndrome; Uveitis; Uveitis - diagnosis; Uveitis - metabolism; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - metabolism
• ISSN: 0165-5701; 1573-2630
• DOI: 10.1007/s10792-019-01112-w

Purpose This study investigated the levels of interleukin (IL)-8, IL-10, and vascular endothelial growth factor (VEGF) in the aqueous humor (AqH) of patients with Behçet’s uveitis (BU) and Fuchs’ uveitis syndrome (FUS) during an inactive period and compared these levels with those in the AqH of noninflammatory healthy control subjects. Methods This prospective and case–control study included 33 patients (16 patients with BU and 17 patients with FUS) and 35 control subjects. IL-8, IL-10, and VEGF levels in the AqH were quantified by performing sandwich enzyme-linked immunosorbent assay. Kruskal–Wallis test was used to compare the cytokine levels in the different groups, and statistical significance was set at p