Non‐natural Photoenzymatic Controlled Radical Polymerization Inspired by DNA Photolyase

Inspired by DNA photolyase, a non‐natural photoenzymatic catalysis of common flavoproteins is developed for controlled radical polymerization under irradiation of visible light. This photoenzymatic polymerization is highly efficient under mild conditions, applicable to various monomer families, suit...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2019-07, Vol.58 (28), p.9479-9484
Main Authors: Zhou, Fanfan, Li, Ruoyu, Wang, Xiao, Du, Simin, An, Zesheng
Format: Article
Language:English
Subjects:
Catalysis
controlled radical polymerization
Deoxygenation
Deoxyribonucleic acid
DNA
enzymes
Flavoproteins
Irradiation
Photolyase
photopolymerization
Polymerization
Radiation
RAFT
visible light
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Summary:Inspired by DNA photolyase, a non‐natural photoenzymatic catalysis of common flavoproteins is developed for controlled radical polymerization under irradiation of visible light. This photoenzymatic polymerization is highly efficient under mild conditions, applicable to various monomer families, suitable for both homogeneous and heterogeneous media, and can be externally modulated by switching light on and off. A unique combination of the natural enzymatic deoxygenation with the non‐natural photoenzymatic process enables an unprecedented oxygen‐tolerant, visible‐light‐controlled radical polymerization using a single enzyme to be developed. Visible light activation of non‐natural catalytic functions of the widely distributed flavoproteins is an exciting conceptual advance and may uncover a hitherto underexplored field of photoenzymatic catalysis. Photoenzymatic reactions are rare in chemistry. Inspired by DNA photolyase, a non‐natural photoenzymatic controlled radical polymerization is developed for common flavoproteins.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201904413