Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy

Recently, there is growing interest in the natural bioactive components having anticancer activity. Thymoquinone (TQ), the principle active constituent of black seed (Nigella sativa), has promising properties including anticancer and chemosensitizing peculiarities. The anticancer power of TQ is acco...

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Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2019-07, Vol.115, p.108783-108783, Article 108783
Main Authors: Mahmoud, Yasmina K., Abdelrazek, Heba M.A.
Format: Article
Language:English
Subjects:
Angiogenesis
Anticancer
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - therapeutic use
Apoptosis
Benzoquinones - chemistry
Benzoquinones - therapeutic use
Humans
Neoplasms - drug therapy
Nigella sativa - chemistry
Phytotherapy
Pro-oxidant
Seeds - chemistry
Thymoquinone
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Summary:Recently, there is growing interest in the natural bioactive components having anticancer activity. Thymoquinone (TQ), the principle active constituent of black seed (Nigella sativa), has promising properties including anticancer and chemosensitizing peculiarities. The anticancer power of TQ is accomplished by several aspects; including promotion of apoptosis, arrest of cell cycle and ROS generation. In addition, it boosts the immune system and lessens the side effects associated with traditional anticancer therapy. TQ also controls angiogenesis and cancer metastasis. This review focuses on the potential aspects and mechanisms by which TQ acquires its actions.
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2019.108783