The role of microRNAs in the involvement of vascular smooth muscle cells in the development of atherosclerosis

MicroRNAs (miRNAs) are a class of nonprotein‐encoding RNAs of ~22 nucleotides in length that bind to or complement each other with a target gene messenger RNA (mRNA) to promote mRNA degradation or inhibit translation of the target mRNA. The protein required [such as Toll‐like receptor (TLR) proteins...

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Bibliographic Details
Published in:Cell biology international 2019-10, Vol.43 (10), p.1102-1112
Main Authors: Li, Linqing, Li, Yongjun, Tang, Chengchun
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Arteriosclerosis
Atherosclerosis
atherosclerosis (AS)
Atherosclerosis - metabolism
Cell differentiation
Cell Proliferation
Humans
Mice
MicroRNAs
microRNAs (miRNAs)
MicroRNAs - physiology
miRNA
mRNA
Muscle, Smooth, Vascular - cytology
Muscle, Smooth, Vascular - metabolism
Myocytes, Smooth Muscle - cytology
Myocytes, Smooth Muscle - metabolism
Nucleotides
phenotypic conversion
Rats
Smooth muscle
Toll-like receptors
Translation
vascular smooth muscle cells (VSMCs)
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Summary:MicroRNAs (miRNAs) are a class of nonprotein‐encoding RNAs of ~22 nucleotides in length that bind to or complement each other with a target gene messenger RNA (mRNA) to promote mRNA degradation or inhibit translation of the target mRNA. The protein required [such as Toll‐like receptor (TLR) proteins] is controlled at an optimal level. By affecting protein translation, miRNAs have become powerful regulators of biological processes, including development, differentiation, cell proliferation, and apoptosis. MiRNAs are involved in the regulation of proliferation, migration, and apoptosis of vascular smooth muscle cells (VSMCs), thereby affecting the formation of atherosclerosis (AS). In recent years, the role and mechanism of miRNAs involved in AS development in VSMCs have been studied extensively. In the current study, the results and progress in miRNA research are reviewed.
ISSN:1065-6995
1095-8355
DOI:10.1002/cbin.11164