Eight new cytotoxic annonaceous acetogenins from the seeds of Annona squamosa

Eight new annonaceous acetogenins, squamotin A-D (1–4), annosquatin IV-V (5 and 6), muricin O (7) and squamosten B (8), together with four known ones (9–12) were isolated from the seeds of Annona squamosa. Their structures were elucidated by chemical methods and spectral data. The inhibitory activit...

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Bibliographic Details
Published in:Chinese journal of natural medicines 2019-04, Vol.17 (4), p.291-297
Main Authors: MA, Cheng-Yao, LU, Jia-Hui, LI, Xiang, LIU, Xiao, CHEN, Jian-Wei
Format: Article
Language:English
Subjects:
Annona squamosa
Annonaceous acetogenins
Cytotoxicity
Multidrug resistance
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Summary:Eight new annonaceous acetogenins, squamotin A-D (1–4), annosquatin IV-V (5 and 6), muricin O (7) and squamosten B (8), together with four known ones (9–12) were isolated from the seeds of Annona squamosa. Their structures were elucidated by chemical methods and spectral data. The inhibitory activities of compound 1–9 against three multidrug resistance cell lines were evaluated. All tested compounds showed strong cytotoxicity.
ISSN:1875-5364
1875-5364
DOI:10.1016/S1875-5364(19)30032-9