Investigating vitamin B12 deficiency

What you need to knowVitamin B12 deficiency may present with non-specific symptoms, but it warrants urgent evaluation and treatment when haematological or neurological features are presentCauses for B12 deficiency include nutritional, drug induced, and gastrointestinal; autoimmune pernicious anaemia...

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Bibliographic Details
Published in:BMJ (Online) 2019-05, Vol.365, p.l1865-l1865
Main Authors: Sukumar, Nithya, Saravanan, Ponnusamy
Format: Article
Language:English
Subjects:
Adult
Aged
Alcoholism
Anemia
Anorexia
Antibodies
Biomarkers - blood
Birth weight
Blood
Celiac disease
Children
Childrens health
Clinical trials
Dementia disorders
Diagnosis
Drug abuse
Eating disorders
Female
Folic Acid - blood
Gastritis
Health Surveys
Homocysteine - blood
Humans
Infant
Infants
Intestinal absorption
Lactation
Malabsorption Syndromes - blood
Malabsorption Syndromes - complications
Malabsorption Syndromes - diagnosis
Male
Malnutrition - blood
Malnutrition - complications
Malnutrition - diagnosis
Maternal & child health
Methylmalonic Acid - blood
Myelination
Older people
pH effects
Physical Examination - methods
Practice Guidelines as Topic
Pregnancy
Referral and Consultation
Renal failure
Risk Factors
Systematic review
United Kingdom - epidemiology
Vitamin B
Vitamin B 12 - blood
Vitamin B 12 - therapeutic use
Vitamin B 12 Deficiency - diagnosis
Vitamin B 12 Deficiency - epidemiology
Vitamin B12
Vitamin deficiency
Vulnerable Populations
Womens health
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Description
Summary:What you need to knowVitamin B12 deficiency may present with non-specific symptoms, but it warrants urgent evaluation and treatment when haematological or neurological features are presentCauses for B12 deficiency include nutritional, drug induced, and gastrointestinal; autoimmune pernicious anaemia is relatively rareConsider specialist referral if there is no obvious cause for B12 deficiency, if it is refractory to treatment, or if neurological features or persistent macrocytic anaemia is presentParenteral B12 replacement is indicated if urgent treatment is required, if gastrointestinal malabsorption is suspected, and in elderly peopleOral B12 replacement may be a suitable alternative in asymptomatic individuals with dietary B12 deficiency
ISSN:0959-8138
1756-1833
DOI:10.1136/bmj.l1865