The crystal and molecular structures of three copper‐containing complexes and their activities in mimicking galactose oxidase

• Published in: Acta crystallographica. Section C, Crystal structure communications Crystal structure communications, 2019-05, Vol.75 (5), p.538-544
• Main Authors: Dimeska, Roza, Wikaira, Jan, Mockler, Garry M., Butcher, Ray J.
• Format: Article
• Language: English
• Subjects: benzoate; Catalysis; Chemical precipitation; Coordination compounds; Copper; Copper compounds; copper(II) complexes; Crystal structure; dimeric cations; Galactose; galactose oxidation; Oxidase; Oxidation; Perchlorate
• ISSN: 2053-2296; 0108-2701; 2053-2296; 1600-5759
• DOI: 10.1107/S2053229619003267

The structures of three copper‐containing complexes, namely (benzoato‐κ2O,O′)[(E)‐2‐({[2‐(diethylamino)ethyl]imino}methyl)phenolato‐κ3N,N′,O]copper(II) dihydrate, [Cu(C7H5O2)(C13H19N2O)]·2H2O, 1, [(E)‐2‐({[2‐(diethylamino)ethyl]imino}methyl)phenolato‐κ3N,N′,O](2‐phenylacetato‐κ2O,O′)copper(II), [Cu(C8H7O2)(C13H19N2O)], 2, and bis[μ‐(E)‐2‐({[3‐(diethylamino)propyl]imino}methyl)phenolato]‐κ4N,N′,O:O;κ4O:N,N′,O‐(μ‐2‐methylbenzoato‐κ2O:O′)copper(II) perchlorate, [Cu2(C8H7O2)(C12H17N2O)2]ClO4, 3, have been reported and all have been tested for their activity in the oxidation of d‐galactose. The results suggest that, unlike the enzyme galactose oxidase, due to the precipitation of Cu2O, this reaction is not catalytic as would have been expected. The structures of 1 and 2 are monomeric, while 3 consists of a dimeric cation and a perchlorate anion [which is disordered over two orientations, with occupancies of 0.64 (4) and 0.36 (4)]. In all three structures, the central Cu atom is five‐coordinated in a distorted square‐pyramidal arrangment (τ parameter of 0.0932 for 1, 0.0888 for 2, and 0.142 and 0.248 for the two Cu centers in 3). In each species, the environment about the Cu atom is such that the vacant sixth position is open, with very little steric crowding. The structures of three copper‐containing complexes are reported and tests for their activity in the oxidation of d‐galactose suggest that, unlike the enzyme galactose oxidase, due to the precipitation of Cu2O, this reaction is not catalytic as would have been expected.